CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037147
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 V-type proton ATPase subunit C 1 
Protein Synonyms/Alias
  
Gene Name
 ATP6V1C1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
62TQIDNDLKSRASAYNubiquitination[1]
72ASAYNNLKGNLQNLEubiquitination[1, 2, 3, 4]
81NLQNLERKNAGSLLTubiquitination[3]
170RHKARENKFIVRDFQubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 307 AA 
Protein Sequence
MADVLEDSKD KVQENLLANG VDLVTYITRF QWDMAKYPIK QSLKNISEII AKGVTQIDND 60
LKSRASAYNN LKGNLQNLER KNAGSLLTRS LAEIVKKDDF VLDSEYLVTL LVVVPKLNHN 120
DWIKQYETLA EMVVPRSSNV LSEDQDSYLC NVTLFRKAVD DFRHKARENK FIVRDFQYNE 180
EEMKADKEEM NRLSTDKKKQ FGPLVRWLKV NFSEAFIAWI HVKALRVFVE SVLRYGLPVN 240
FQAMLLQPNK KTLKKLREVL HELYKHLDSS AAAIIDAPMD IPGLNLSQQE YYPYVYYKID 300
CNLLEFK 307 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0033180; C:proton-transporting V-type ATPase, V1 domain; IEA:InterPro.
 GO:0008553; F:hydrogen-exporting ATPase activity, phosphorylative mechanism; IEA:Compara.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro. 
Interpro
 IPR004907; ATPase_V1-cplx_csu. 
Pfam
 PF03223; V-ATPase_C 
SMART
  
PROSITE
  
PRINTS