CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038349
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Neb 
Protein Synonyms/Alias
  
Gene Name
 Neb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
59LAQPQPAKPVERKKVubiquitination[1]
104KENYEKAKGQPYAITubiquitination[1]
353DYEKNKGKADYNVLPubiquitination[1]
478TQEYEAIKKLDQCKDubiquitination[1]
562VYKQDWEKSKAKKFDubiquitination[1]
581AIPLLAAKANSKNASubiquitination[1]
649MNYCETPKYQLDTLLubiquitination[1]
657YQLDTLLKNFSEAKYubiquitination[1]
1069RIDAIPIKAAKAARQubiquitination[1]
1316AIPITAAKSSRNIASubiquitination[1]
1432IQSDNVYKDEYNSFFubiquitination[1]
1560AIPIVAAKSSRNIASubiquitination[1]
1814RDIASDYKYKQAYEQubiquitination[1]
1878FSVVAAKKSQEVATNubiquitination[1]
2045RTDAIPIKAAKASRDubiquitination[1]
2133NITNTNYKRLIHKYIubiquitination[1]
2186AGSLEVEKAKKATEYubiquitination[1]
2265NQTLYSQKSYRLGWEubiquitination[1]
2292AISVQLAKTSRDIASubiquitination[1]
2302RDIASDFKYKQGYRKubiquitination[1]
2450RQPPDRNKFTSIPDAubiquitination[1]
2532PVDAIPIKAAKASREubiquitination[1]
2608MLGVVLAKKCQTLVSubiquitination[1]
3474IMLARQNKINYSESLubiquitination[1]
3644IGSLEVVKAKRATEIubiquitination[1]
4132SIEMTRVKGAQDLVNubiquitination[1]
4213ISNKLYQKDWDEAKQacetylation[2]
4860VDHVRVTKNQEMVNQubiquitination[1]
5236KALYTLPKSVDDDPNubiquitination[1]
5385PVYVQAVKSGKQLSDubiquitination[1]
5388VQAVKSGKQLSDAVYubiquitination[1]
5600VRSRHLRKLWSNYLYubiquitination[1]
5816TDAVSDVKYKEDLTWubiquitination[1]
5818AVSDVKYKEDLTWLKubiquitination[1]
5950LRTTKVNKQISDILYubiquitination[1]
6064QQSDFEYKLDREFLKubiquitination[1]
6081KLSVTDDKDMVLALRubiquitination[1]
6097SLIESDLKYKEKHVKubiquitination[1]
6234KKATQAAKQASEVEYubiquitination[1]
6293KTPKYNPKDSQLYKTubiquitination[1]
6312NNLASEVKYKADLKKubiquitination[1]
6481TPDMLRAKNATQILNubiquitination[1]
6490ATQILNEKEYKRDLEubiquitination[1]
6529TDIASQIKYKQSAEMubiquitination[1]
6918QRHISTVKYHEDFEKubiquitination[1]
6927HEDFEKHKGCFTPVVubiquitination[1]
6944PITERVKKNTQDFSDubiquitination[1]
6967KVVEMEQKRNDQDQDubiquitination[1]
7033SISGGEEKSEHSEAAubiquitination[1]
7062SATSTAYKHVKTTQLubiquitination[1]
7065STAYKHVKTTQLPQQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 7152 AA 
Protein Sequence
MADEEEYEEV IEYYTEETVY EEVPGETITE VYETTTTRTS DYGQSETATP ALAQPQPAKP 60
VERKKVIRKK VDSSKFMTPY IQHSQKMQDL FSSNKYKENY EKAKGQPYAI TSDTPELRRI 120
KKVQDQLSEV KYRMDGDVAK TICHVDEKAK DIEHAKKVSQ QVSKVLYKQN WEDTKDKYLL 180
PPDAPELVQA VKNTAMFSKK LYTEDWEADK ALFYPYNDSP ELRRVAQAQK ALSDIAYKKG 240
LTEQQTQFTS LPDPPEVEFA KKVTNQVSKQ KYKEDYEKKV KGKWSETPCF EIATARMNAD 300
NLSSRKYQED FENMKDQIYF MQTETPEYKM NKQAGVAASK VKYKQDYEKN KGKADYNVLP 360
ASENPLLRQL KTAGNVLSDK LYKENYEKTK ARSINYCETP KFQLDTVLQN FSSDTKYKDS 420
YLKNILGHYV GSFEDPYHTH CMKVTAQNSD KNYKAEYEED RGKGFFPQTI TQEYEAIKKL 480
DQCKDHAYKV HPDKTKFTQV TDSPVLVQAQ VNSKQLSDLN YKAKHESEKF KCHIPPDAPA 540
FIQHRVNAYN LSDNVYKQDW EKSKAKKFDI KVDAIPLLAA KANSKNASDV MYKKDYEKSK 600
GKMIGALSIN DDPKMLHSLK TAKNQSDRLY RENYEKTKAK SMNYCETPKY QLDTLLKNFS 660
EAKYKDSYVK NMLGHYVGSF EDPYHTHCMK VSAQNSDKSY KAEYEEDKGK CYFPQTITQE 720
YESIKKLDQC KDHTYKVHPD KTRFTAVTDT PVLLQAQLNT KQLSDLNYKA KHEGEKFKCS 780
VPADAPEFIQ HRVNAYNLSD NVYKHDWEKS KAKKFDIKVD AIPLLAAKAN SKNASDVMYK 840
KDYEKSKGKM IGALSINDDP KMLHSLKTAK NQSDREYRKD YEKSKTIYTA PLDMIQVTQA 900
KKSQAIASDV DYKHVLHNYS YPPDSINVDL AKKAYALQSD VEYKADYNSW MKGCGWVPFG 960
SLEMEKAKRA SEILNEKKYR QHPDTLKFTS IEDAPITVQS KINQAQRSDI AYKAKGEEIL 1020
HKYNLPADLP QFIQAKVNAY NISENMYKAD LKDLSKKGYD LRIDAIPIKA AKAARQAASD 1080
IHYKKDYEKA KGKMVGFQSL QDDPKLVHYM NVAKIQSDRE YKKDYEKTKT KYNTPHDMFD 1140
VVAAKKAQDV ISNTNYKHSL HHYTYLPDAM DLELSKNMMH IQSDNAYKED YNTWMKGIGW 1200
IPIGSLDQEK VKKAGDALSE KKYRQHPDTL KFTSIVDSPV MVQAKQNTQQ ASDILYKAKG 1260
EDVKHKYTLN PDLPQFLQAK CNAYNISDVC YKRDWHDLIA KGNNVLADAI PITAAKSSRN 1320
IASDYKYKEA YEKAKGKHVG FRSLQDDPKL VHYMNVAKLQ SDREYKKNYE NTKTSYHTPG 1380
DMVSITAARM AQDVATNVNY KQPLHHYTYL PDALSLEHTR NANQIQSDNV YKDEYNSFFK 1440
GIGWIPIGSL EVEKAKKAGE ALNERKYRQH PDTIKFTSVP DSMGMVLAQQ NTKQLSDLNY 1500
KVEGEKMKHK YTMDPELPQF IQAKVNAINM SDAHYKADWK KTLAKGYDLR PDAIPIVAAK 1560
SSRNIASDCK YKEAYEKARG KQIGFLSLQD DPKLVHYMNV AKIQSDREYK KGYEASKTRY 1620
HTPLDMFSVT AAKKSQEVAT NSNYRQPYHN YTLLPDALNV EHSRNAMQIQ SDNLYKSDFT 1680
HWMKGIGWVP IDSLEVEKAK KAGEILSERK YRQHPEKLKF TYSMDTMEQA LNKSNKLTMD 1740
KRLYTEKWNK DKTSIHVMPD TPDILLSRVN QITMSDKLYK AGWEEEKTKG YDLKPDAIAI 1800
KAAKASRDIA SDYKYKQAYE QSKGKHIGFR SLEDDPKLVH FMQVAKIQSD REYKKGYEKS 1860
KTSFHTPVDM FSVVAAKKSQ EVATNANYRN IIHTYNMLPD AMSFELAKNM MQIQSDNQYK 1920
ADYADFMKGI GWLPLGSLEA EKNKKAMEII SEKKYRQHPD TLKYSTLMDS MNMVLAQNNA 1980
KIMNKNLYKQ AWEADKTKIH IMPDIPEIVL AKANAINMSD KLYKLSLEES RKKGYDLRTD 2040
AIPIKAAKAS RDIASDYKYK HSYEKEKGKM VGFRSLEDDP KLVHSMQVAK MQSDREYKKN 2100
YEKTKTSYHT PADMLSVTAA KDAQANITNT NYKRLIHKYI LLPDAMNIEL TRNMNHIQSD 2160
NEYKQDYREW YRGLGWSPAG SLEVEKAKKA TEYASDQKYR QHPSTFQFKK LTDSMDMVLA 2220
KQNAHTMNKH LYTIDWNKDK TKIHVMPDTP DILQAKQNQT LYSQKSYRLG WEEALKKGYD 2280
LPVDAISVQL AKTSRDIASD FKYKQGYRKQ LGHHIGFLSV QDDPKLVLSM NVAKMQSDRE 2340
YKKDFEKWKT KYTSPVDMLG VVLAKKCQAL VSDADYRNYL HQWTCLPDQN DVIQAKKVYE 2400
LQSENMYKSD LEWLRGIGWS PLGSLEAEKN KRASEIISEK KYRQPPDRNK FTSIPDAMDI 2460
VLAKTNAKNR SDRLYREAWD KDKTQIHIMP DTPDIILAKA NLINTSDKLY KMGYEELKKK 2520
GYDLPVDAIP IKAAKASREI ASEYKYKEGF RKQLGHHIGA RNIKDDPKMM WSMHVAKIQS 2580
DREYKKDFEK WKTKYSSPVD MLGVVLAKKC QTLVSDADYR NYLHQWTCLP DQNDVIHARQ 2640
AYDLQSDNVY KADLQWLKGI GWIPSGSLED EKNKRATQIL SDHVYRQHPN KFKFSSLMDS 2700
MPMVLAKNNA ITMNHHLYTE AWNKDKTTVH IMPDTPEVIL AKQNKVNYSE KLYKLGLEEA 2760
KRKGYDMRLD AIPIKTAKAS RDIASDFKYK EGYRKQLGHH IGARGIHDDP KMMWSMHVAK 2820
IQSDREYKKD FEKWKTKYSS PVDMLGVVLA KKCQTLVSDA DYRNYLHQWT CLPDQNDVIH 2880
ARQAYDLQSD NMYKSDLQWM RGIGWVPIGS LDVEKCKRAT EILSDKIYRQ PPDKFKFTSV 2940
TDSLEQVLAK NNAITMNKRL YTEAWDKDKT QIHIMPDTPE IMLARMNKVN YSESLYKLAN 3000
EEAKKKGYDL RSDAIPIVAA KASRDIASDY KYKDGYRKQL GHHIGARNIK DDPKMMWSMH 3060
VAKIQSDREY KKDFEKWKTK YSSPVDMLGV VLAKKCQILV SDIDYKHPLH EWTCLPDQND 3120
VIHARQAYDL QSDNVYKSDL QWMRGIGWVP IGSLDVVKCK RAAEILSDNI YRQPPNKFKF 3180
TSVTDSLEQV LAKSNALNMN KRLYTEAWDK DKIQIHVMPD TPEIMLARQN RINYSESLYK 3240
LANEEAKKKG YDLRVDAIPI VAAKASRDIA SDYKYKVGYR KQLGHHIGAR NIEDDPKMMW 3300
SMHVAKIQSD REYKKDFEKW KTKYSSPVDM LGVVLAKKCQ TLVSDVDYRN YLHQWTCLPD 3360
QNDVIHARQA YDLQSDNVYK SDLQWMRGIG WVPIGSLDVV KCKRAAEILS DNIYRQPPNK 3420
FKFTSVTDSL EQVLAKSNAL NMNKRLYTEA WDKDKTQIHI MPDTPEIMLA RQNKINYSES 3480
LYRQAMEEAK KEGYDLRSDA IPIVAAKASR DIASDYKYKE AYRKQLGHHI GARAIHDDPK 3540
MMWSLHIAKV QSDREYKKEF EKYKTRYSSP VDMLGIVLAK KCQTLVSDVD YKHPLHEWTC 3600
LPDQNDVIQA RKAYDLQSDN LYKADLEWMK GIGWVPIGSL EVVKAKRATE ILSDNIYRQR 3660
PDTLKFTSIT DSLEQVLAKN NAITMNKRLY TEAWDNDKKT IHVMPDTPEI MLAKLNRINY 3720
SDKLYKVSLE EARRQGYDLR VDAIPIRSAK ASREIASDYK YKEGYRKQLG HHIGARNIKD 3780
DPKMMWSMHV AKIQSDREYK KDFEKWKTKY SSPVDMLGVV LAKKCQILVS DIDYKHPLHE 3840
WTCLPDQNDV IQARKAYDLQ SDAVYKADLE WLRGIGWVPI GSVEVEKVKR AGEILSDRKY 3900
RQPADQLKFT CITDTPEIVL AKSNAITMSK HLYTEAWDAD KASIHVMPDT PEILLAKSNS 3960
ANISHKLYTK GWDESKMKDY DLREDAISIK SAKASRDIAS DYKYKEAYEK QKGHHIGAQS 4020
VEDDPRILCA MHAGKIYSDR EYKKEFQKWK TKFSSPVDML GVVLAKKCQT LVSDVDYRNY 4080
LHNWTCLPDQ NDIIQAKKAY ELQSDSVYKA DLEWLRGIGW MPEGSIEMTR VKGAQDLVNE 4140
RLYRTRPEAL KFTSIVDTPE VVLAKANSLQ MSERLYQEAW NKDKTNISLP LDTPAMLQAQ 4200
INALQISNKL YQKDWDEAKQ KGYDLRADAI EIKHAKASRE IASEYKYKEG YRKQLGHHVG 4260
FRSLQDDPKL VWSIHAAKIQ SDREYKKAYE KSKGIYNTPL DMMSIVQAKK CQVLVSDVDY 4320
RNYLHQWTCL PDQNDVIQAK KAYELQSDAI YKADLEWLRG IGWMPEGSPE VLRVKNAQEI 4380
LCDSVYRTPV VKLKYTSIVD TPEVVLAKSN AENISIPKYR EVWDKDKTSI HIMPDTPEIN 4440
LARANALNVS NKLYREGWDE VKMSCDVRLD AIPIQAAKAS REIASDYKYK LDHEKQKGHY 4500
VGTLTARDDN KIRWALIAGK IQNEREYRLQ WAKWKTKFQS PVDMLSILHS KKCQTLVSDI 4560
DYRNYLHEWT CMPDQNDVIQ AKKAYELQSD AVYKADLEWL RGIGWMPNDS VSVNHAKHAA 4620
DIFSEKKYRT KIETLNFTPV DDRVDYVTAK QSSEIRDDIK YRKDWNAIKS KYTLTETPLL 4680
HTAQEAARIL DQYLYKEGWE KQKATGYILP PDAVPFVHAH HSSDVQSELK YKAEHVKQRG 4740
HYVGVPTMRD DPKLVWFEHA GQIQNDRLYK ESYHKSKAKI NIPADMVSVV AAKEGQNLVS 4800
DIDYRQYLHQ WTCHPDQNDV IQAKIAYDLQ SDNVYKADLE WLRGIGWIPL DSVDHVRVTK 4860
NQEMVNQIKY KKDALANYPN FTSVEDPPEI VLAKINSVNQ SDVKYKETFN KAKGKYIFSP 4920
DTPYISHSKD MGKLYSTILY KGAWEGTKAY GYTLDERYIP IVGAKHADLV NSELKYKETY 4980
EKQKGHYLAG KEISEFPGVV HCLDFQQMRS ALNYRRDYED TKANVHIPND MMNHVLAKRC 5040
QYILSDLEYR HYFHQWTSLP EEPNVIRARN AQEILSDNVY KDDLNWLKGI GCYVWDTPQI 5100
LHAKKSYDLQ SQLQYTAASK ENLQNYNLVT DTPVYVTALQ SGINASEVKY KENYHQIKDK 5160
YTTVLETADY DRTKHLKSLY SSNIYKEAWD KVKATSYNLP TSTLSLTHAK NQKHLASHIK 5220
YREEYEKFKA LYTLPKSVDD DPNTARCLRV GKLNIDRLYR SVYEKNKMKI NIVPDMVEMV 5280
TAKDSQKKVS EIDYRLHLHE WICHPDLQVN SHVRKVTDQI SDIVYKDDLT WLKGIGCYVW 5340
DTPEILHAKH AYDLRNDIKY KAHVQKTRND YKLVTDTPVY VQAVKSGKQL SDAVYHYDYV 5400
HSVRGKVAPT TKTVDLDRAL HAYKLQSENL YKKGLRFLPT GYRLPVDTPH FNHTKDTRYM 5460
SSYFKYKEAY EHIKANGYTL GPKDVPFVHV RRVNNVTSER LYRELYHKLK DKIHTTPDTP 5520
EIRQVKKTQE AVSELIYKSD FFKMQGHMIS LPYTPQVLHC RYVGDITSDI KYKEDLQILK 5580
GLGCFLYDTP DMVRSRHLRK LWSNYLYTDN ARKMRDKYKV VLDTPEYRKV QELKTHLSEL 5640
VYRASGKKQK SIFTSVPDTP DLLRAKRGQK LQSQYLYVEL ATKERPHHHA GNQTTALQHA 5700
KDVKDMVSEK KYKIQYEKMK DKYTPVADTP ILIRAKRAYW NASDLRYKET FQKTKGRYHT 5760
VKDALDIVYH RKVTDDISKV KYKENYMSQL GIWSSIPDRP EHFHHRAVTD AVSDVKYKED 5820
LTWLKGIGCY AYDTPDLTLA EQNKTLYSKY KYKEVFERTK SNFKYVADCP INRHFKYATQ 5880
LMNEKKYRAD YEQRKDKYHL VVDEPRHLLA KTAGDQISQI KYRKKYEKSK DKFTSVVDTP 5940
EHLRTTKVNK QISDILYKLE YNKARPRGYT TIHDTPMLLH VRKVKDEVSD LKYKEVYQRN 6000
KSNCTIKPDA VHIKAAKDAY KVNTNLDYKK QYEANKAYWK WTPDRPDFIQ AAKSSLQQSD 6060
FEYKLDREFL KGCKLSVTDD KDMVLALRNS LIESDLKYKE KHVKERGSCH AVPDTPQILL 6120
AKTVSNLVSE NKYKDHVKKH LAQGSYTTLP ETRDTVHVKA VTKHVSDTNY KKKFVKEKGK 6180
SNYSIMQEPP EVKHAMEVAK KQSDVAYKKD AKENLHYTTV ADRPDIKKAT QAAKQASEVE 6240
YRAKHRKEGS HGLSMLGRPD IEMAKKAAKL SSQVKYRENF DKEKGKTPKY NPKDSQLYKT 6300
MKDANNLASE VKYKADLKKL HKPVTDMKES LIMHHVLNTS QLASSYQYKK NYEKSKGHYH 6360
TIPDNLEQLH HREATELQSI VKYKEKYEKE RGKPMLDFET PTYITAKESQ QMQSGKEYRK 6420
DYEESIKGRN LTGLEVTPAL LHVRHATKIA SEKEYRKDLE ESIRGRGLTE MEDTPDMLRA 6480
KNATQILNEK EYKRDLELEV KGRGLNAMAN ETPDFMRARN ATDIASQIKY KQSAEMEKAN 6540
FTSVVDTPEI IHAQQVKNLS SQKKYKEDAE KSMSYYETVL DTPEMQRVRE NQKNFSLLQY 6600
QCDLKNSKGK ITVVQDTPEI LRVKENQKNF SSVLYKEDVS PGTAIGKTPE MLRVKQTQDH 6660
ISSVKYKEAI GQGTPIPDLP EVKRVKETQK HISSVMYKEN PGTGIPTTVT PEIERVKRNQ 6720
ENFSSVLYKE SLGKGTPTAI TPEMERVKRN QENFSSVLYK ENMGKGTPLP VTPEMERVKH 6780
NQENISSVLY KENVGKATPT PVTPEMQRVK RNQENISSVL YKENMGKATP TPFTPEMERV 6840
KRNQENFSSV LYKENMRKAT PTPVTPDMER AKRNQENISS VLYSDSFRKQ IQGKAAYVLD 6900
TPEMRRVRET QRHISTVKYH EDFEKHKGCF TPVVTDPITE RVKKNTQDFS DINYRGIQRK 6960
VVEMEQKRND QDQDTITGLR VWRTNPGSVF DYDPAEDNIQ SRSLHMINVQ AQRRSRDQSR 7020
SASALSISGG EEKSEHSEAA DQRLSTYSDG GAFFSATSTA YKHVKTTQLP QQRSSSVATQ 7080
QTTLSSIPSH PSTAGKIFRA IYDYIAADAD EVSFKDGDAI VNAQAIDEGW MYGTVQRTGR 7140
TGMLPANYVE AI 7152 
Gene Ontology
 GO:0043234; C:protein complex; ISO:MGI.
 GO:0005865; C:striated muscle thin filament; TAS:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0030832; P:regulation of actin filament length; TAS:MGI.
 GO:0045214; P:sarcomere organization; TAS:MGI. 
Interpro
 IPR013998; Nebulin.
 IPR000900; Nebulin_35r-motif.
 IPR001452; SH3_domain. 
Pfam
 PF00880; Nebulin
 PF00018; SH3_1 
SMART
 SM00227; NEBU
 SM00326; SH3 
PROSITE
 PS51216; NEBULIN
 PS50002; SH3 
PRINTS
 PR00510; NEBULIN.