CPLM-001562

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-001562

UniProt Accession

ATE1_HUMAN; O95260; O95261; Q5SQQ3; Q8WW04

Genbank Protein ID

AL731542; AC025947; AL731566; AL731566; AC025947; AL731542; CH471066; BC022026; AF079098; AF079099

Genbank Nucleotide ID

CAI12918.1; CAI12918.1; CAI12918.1; CAI14813.1; CAI14813.1; CAI14813.1; EAW49334.1; AAH22026.2; AAD12366.1; AAD12367.1

Protein Name

Arginyl-tRNA--protein transferase 1

Protein Synonyms/Alias

Arginyltransferase 1; R-transferase 1; Arginine-tRNA--protein transferase 1

Gene Name

ATE1

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
269	LPENASHKLEVRVVR	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).

Sequence Annotation

MOD_RES 169 169 Phosphoserine.

Keyword

Acyltransferase; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Transferase; Ubl conjugation pathway.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

518 AA

Protein Sequence

MAFWAGGSPS VVDYFPSEDF YRCGYCKNES GSRSNGMWAH SMTVQDYQDL IDRGWRRSGK 60
YVYKPVMNQT CCPQYTIRCR PLQFQPSKSH KKVLKKMLKF LAKGEVPKGS CEDEPMDSTM 120
DDAVAGDFAL INKLDIQCDL KTLSDDIKES LESEGKNSKK EEPQELLQSQ DFVGEKLGSG 180
EPSHSVKVHT VPKPGKGADL SKPPCRKAKE IRKERKRLKL MQQNPAGELE GFQAQGHPPS 240
LFPPKAKSNQ PKSLEDLIFE SLPENASHKL EVRVVRSSPP SSQFKATLLE SYQVYKRYQM 300
VIHKNPPDTP TESQFTRFLC SSPLEAETPP NGPDCGYGSF HQQYWLDGKI IAVGVIDILP 360
NCVSSVYLYY DPDYSFLSLG VYSALREIAF TRQLHEKTSQ LSYYYMGFYI HSCPKMKYKG 420
QYRPSDLLCP ETYVWVPIEQ CLPSLENSKY CRFNQDPEAV DEDRSTEPDR LQVFHKRAIM 480
PYGVYKKQQK DPSEEAAVLQ YASLVGQKCS ERMLLFRN 518

Gene Ontology

GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0004057; F:arginyltransferase activity; TAS:UniProtKB.
GO:0016598; P:protein arginylation; NAS:UniProtKB.

Interpro

IPR016181; Acyl_CoA_acyltransferase.
IPR017137; Arg-tRNA-P_Trfase_1_euk.
IPR007472; Arg-tRNA-P_Trfase_C.
IPR007471; Arg_tRNA_PTrfase_N.

Pfam

PF04377; ATE_C
PF04376; ATE_N

SMART

PROSITE

PRINTS