CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017736
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centrosomal protein of 70 kDa 
Protein Synonyms/Alias
 Cep70; p10-binding protein 
Gene Name
 CEP70 
Gene Synonyms/Alias
 BITE 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
53LVKRTDLKDLIIFDKubiquitination[1]
60KDLIIFDKQSSQRMRubiquitination[1]
123EQIMESVKSKIGELEubiquitination[1, 2]
125IMESVKSKIGELEDEubiquitination[1]
202RVFAYLCKRVPHTVLubiquitination[1]
256LDASPTYKGLLMSLQubiquitination[1]
267MSLQNQLKESKSKIDubiquitination[1]
272QLKESKSKIDALSSEubiquitination[1]
280IDALSSEKLNLQKDLubiquitination[1]
285SEKLNLQKDLETRPTubiquitination[1]
300QHELRLYKQQVKKLEubiquitination[1]
315KALKKNVKLQELINHubiquitination[1]
323LQELINHKKAEDTEKubiquitination[1]
324QELINHKKAEDTEKKubiquitination[1]
370RAPVIIYKQTKGGVQubiquitination[1]
427LVPWLNLKKQDENEGubiquitination[2]
428VPWLNLKKQDENEGIubiquitination[1]
593VPAVKKLKVLSY***ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle. 
Sequence Annotation
 REPEAT 483 516 TPR.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 597 AA 
Protein Sequence
MFPVAPKPQD SSQPSDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT DLKDLIIFDK 60
QSSQRMRQNL KLLVEETSCQ QNMIQELIET NQQLRNELQL EQSRAANQEQ RANDLEQIME 120
SVKSKIGELE DESLSRACHQ QNKIKDLQKE QKTLQVKCQH YKKKRTEQEE TIASLQMEVC 180
RLKKEEEDRI VTQNRVFAYL CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS 240
EEENDYRNLD ASPTYKGLLM SLQNQLKESK SKIDALSSEK LNLQKDLETR PTQHELRLYK 300
QQVKKLEKAL KKNVKLQELI NHKKAEDTEK KDEPSKYNQQ QALIDQRYFQ VLCSINSIIH 360
NPRAPVIIYK QTKGGVQNFN KDLVQDCGFE HLVPVIEMWA DQLTSLKDLY KSLKTLSAEL 420
VPWLNLKKQD ENEGIKVEDL LFIVDTMLEE VENKEKDSNM PHFQTLQAIV SHFQKLFDVP 480
SLNGVYPRMN EVYTRLGEMN NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQV 540
MQVLGPEDLQ SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY 597 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome. 
Interpro
 IPR013026; TPR-contain_dom.
 IPR019734; TPR_repeat. 
Pfam
  
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS