UniProt Accession

 MET15_HUMAN; A6NJ78; A8MRS5; B7WNU2; Q3MHD3; Q8N601; Q8NBA7 

Genbank Protein ID

 AK091298; AC023206; AC087376; CH471064; CH471064; BC030997; BC105287 

Genbank Nucleotide ID

 BAC03631.1; EAW68267.1; EAW68266.1; AAH30997.1; AAI05288.1 

Protein Name

 Probable methyltransferase-like protein 15 

Protein Synonyms/Alias

 Methyltransferase 5 domain-containing protein 1 

Gene Name

 METTL15 

Gene Synonyms/Alias

 METT5D1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
188	ERGFSLRKDGPLDMR	ubiquitination	[1]
352	SVRQQVMKTSQLGSD	ubiquitination	[2, 3]
380	LMWELIHKKVLSPQD	ubiquitination	[2, 3]
381	MWELIHKKVLSPQDQ	ubiquitination	[2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Probable S-adenosyl-L-methionine-dependent methyltransferase (By similarity). 

Sequence Annotation

 REGION 100 102 S-adenosyl-L-methionine binding (By
 BINDING 119 119 S-adenosyl-L-methionine (By similarity).
 BINDING 146 146 S-adenosyl-L-methionine; via amide
 BINDING 169 169 S-adenosyl-L-methionine (By similarity).
 BINDING 176 176 S-adenosyl-L-methionine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Methyltransferase; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 407 AA 

Protein Sequence

Gene Ontology

 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW. 

Interpro

 IPR002903; RsmH.
 IPR023397; SAM-dep_MeTrfase_MraW_recog. 

Pfam

 PF01795; Methyltransf_5 

SMART

  

PROSITE

  

PRINTS