CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012215
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 General transcription factor IIH subunit 2 
Protein Synonyms/Alias
 Basic transcription factor 2 44 kDa subunit; BTF2 p44; General transcription factor IIH polypeptide 2; TFIIH basal transcription factor complex p44 subunit 
Gene Name
 GTF2H2 
Gene Synonyms/Alias
 BTF2P44 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23ERTWEILKEDESGSLubiquitination[1, 2]
31EDESGSLKATIEDILubiquitination[1]
40TIEDILFKAKRKRVFubiquitination[1, 2]
77TMEDQDLKPNRLTCTubiquitination[1, 2]
116TKSKRAEKLTELSGNubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter. 
Sequence Annotation
 DOMAIN 60 236 VWFA.
 ZN_FING 291 308 C4-type.
 MOD_RES 95 95 Phosphotyrosine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; DNA damage; DNA repair; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 395 AA 
Protein Sequence
MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH GQVRLGMMRH 60
LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP ISQIGIIVTK SKRAEKLTEL 120
SGNPRKHITS LKKAVDMTCH GEPSLYNSLS IAMQTLKHMP GHTSREVLII FSSLTTCDPS 180
NIYDLIKTLK AAKIRVSVIG LSAEVRVCTV LARETGGTYH VILDESHYKE LLTHHVSPPP 240
ASSSSECSLI RMGFPQHTIA SLSDQDAKPS FSMAHLDGNT EPGLTLGGYF CPQCRAKYCE 300
LPVECKICGL TLVSAPHLAR SYHHLFPLDA FQEIPLEEYN GERFCYGCQG ELKDQHVYVC 360
AVCQNVFCVD CDVFVHDSLH CCPGCIHKIP APSGV 395 
Gene Ontology
 GO:0000439; C:core TFIIH complex; IEA:InterPro.
 GO:0005675; C:holo TFIIH complex; IDA:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:ProtInc.
 GO:0008135; F:translation factor activity, nucleic acid binding; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006370; P:7-methylguanosine mRNA capping; TAS:Reactome.
 GO:0002031; P:G-protein coupled receptor internalization; IMP:UniProtKB.
 GO:0000718; P:nucleotide-excision repair, DNA damage removal; TAS:Reactome.
 GO:0050434; P:positive regulation of viral transcription; TAS:Reactome.
 GO:0006468; P:protein phosphorylation; IDA:GOC.
 GO:0009411; P:response to UV; TAS:ProtInc.
 GO:0006363; P:termination of RNA polymerase I transcription; TAS:Reactome.
 GO:0006362; P:transcription elongation from RNA polymerase I promoter; TAS:Reactome.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
 GO:0006361; P:transcription initiation from RNA polymerase I promoter; TAS:Reactome.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
 GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 
Interpro
 IPR007198; Ssl1-like.
 IPR004595; TFIIH_C1-like_dom.
 IPR012170; TFIIH_SSL1/p44.
 IPR002035; VWF_A.
 IPR007087; Znf_C2H2. 
Pfam
 PF07975; C1_4
 PF04056; Ssl1 
SMART
 SM01047; C1_4
 SM00327; VWA 
PROSITE
 PS50234; VWFA 
PRINTS