UniProt Accession

 CYPD_YEAST; P35176; D6VST3 

Genbank Protein ID

 X73142; U28374; AY557734; BK006938 

Genbank Nucleotide ID

 CAA51658.1; AAB64740.1; AAS56060.1; DAA12143.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase D 

Protein Synonyms/Alias

 PPIase D; Cyclophilin D; Rotamase D 

Gene Name

 CPR5 

Gene Synonyms/Alias

 CYP5; CYPD; YDR304C; D9740.14 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
45	FDINHGDKQIGRIVM	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. 

Sequence Annotation

 DOMAIN 37 195 PPIase cyclophilin-type.
 MOTIF 222 225 Prevents secretion from ER.
 CARBOHYD 139 139 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Cyclosporin; Endoplasmic reticulum; Glycoprotein; Isomerase; Reference proteome; Rotamase; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 225 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0042277; F:peptide binding; IEA:UniProtKB-KW.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; ISS:SGD.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW. 

Interpro

 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR024936; Cyclophilin-type_PPIase.
 IPR020892; Cyclophilin-type_PPIase_CS. 

Pfam

 PF00160; Pro_isomerase 

SMART

  

PROSITE

 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2
 PS00014; ER_TARGET 

PRINTS

 PR00153; CSAPPISMRASE.