UniProt Accession

 CAZA1_RAT; B2GUZ5 

Genbank Protein ID

 BC166464 

Genbank Nucleotide ID

 AAI66464.1 

Protein Name

 F-actin-capping protein subunit alpha-1 

Protein Synonyms/Alias

 CapZ alpha-1 

Gene Name

 Capza1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
19	EKVRIAAKFITHAPP	acetylation	[1]
97	PRNKISFKFDHLRKE	acetylation	[1]
118	EDVDGGLKSWRDSCD	acetylation	[1]
273	RTKIDWNKILSYKIG	acetylation	[1]
273	RTKIDWNKILSYKIG	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 19 19 N6-acetyllysine (By similarity).
 MOD_RES 97 97 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin capping; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 286 AA 

Protein Sequence

Gene Ontology

 GO:0030863; C:cortical cytoskeleton; IEA:Compara.
 GO:0008290; C:F-actin capping protein complex; IEA:InterPro.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0071203; C:WASH complex; ISS:UniProtKB.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0051693; P:actin filament capping; IEA:UniProtKB-KW. 

Interpro

 IPR017865; F-actin_cap_asu_CS.
 IPR002189; WASH_F-actin_cap_alpha. 

Pfam

 PF01267; F-actin_cap_A 

SMART

  

PROSITE

 PS00748; F_ACTIN_CAPPING_A_1
 PS00749; F_ACTIN_CAPPING_A_2 

PRINTS

 PR00191; FACTINCAPA.