| Tag | Content |
|---|
| CPLM ID | CPLM-002966 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Peptide methionine sulfoxide reductase MsrA |
Protein Synonyms/Alias | Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase |
Gene Name | msrA |
Gene Synonyms/Alias | pms; b4219; JW4178 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 6 | **MSLFDKKHLVSPA | acetylation | [1] | | 7 | *MSLFDKKHLVSPAD | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Could have an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. |
Sequence Annotation | ACT_SITE 52 52 Cysteine sulfenic acid (-SOH)
DISULFID 52 199 Redox-active; alternate (Probable).
DISULFID 199 207 Redox-active; alternate (Probable). |
Keyword | 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Oxidoreductase; Redox-active center; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 212 AA |
Protein Sequence | MSLFDKKHLV SPADALPGRN TPMPVATLHA VNGHSMTNVP DGMEIAIFAM GCFWGVERLF 60
WQLPGVYSTA AGYTGGYTPN PTYREVCSGD TGHAEAVRIV YDPSVISYEQ LLQVFWENHD 120
PAQGMRQGND HGTQYRSAIY PLTPEQDAAA RASLERFQAA MLAADDDRHI TTEIANATPF 180
YYAEDDHQQY LHKNPYGYCG IGGIGVCLPP EA 212 |
Gene Ontology | GO:0005829; C:cytosol; IDA:EcoCyc. GO:0008113; F:peptide-methionine (S)-S-oxide reductase activity; IEA:HAMAP. GO:0006464; P:cellular protein modification process; IEA:HAMAP. |
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Pfam | |
SMART | |
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