UniProt Accession

 OYE2_YEAST; Q03558; D3DLC8; E9P8V8 

Genbank Protein ID

 L06124; U00027; AY558286; BK006934 

Genbank Nucleotide ID

 AAA83386.1; AAB68024.1; AAS56612.1; DAA06872.1 

Protein Name

 NADPH dehydrogenase 2 

Protein Synonyms/Alias

 Old yellow enzyme 2 

Gene Name

 OYE2 

Gene Synonyms/Alias

 YHR179W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
8	MPFVKDFKPQALGDT	acetylation	[1]
19	LGDTNLFKPIKIGNN	acetylation	[1]
22	TNLFKPIKIGNNELL	acetylation	[1]
103	KEWTKIFKAIHENKS	acetylation	[1]
151	MNAEQEEKAKKANNP	acetylation	[1]
164	NPQHSITKDEIKQYV	acetylation	[1]
168	SITKDEIKQYVKEYV	acetylation	[1]
172	DEIKQYVKEYVQAAK	acetylation	[1]
363	DLVDRLEKGLPLNKY	acetylation	[1]
369	EKGLPLNKYDRDTFY	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Oxidizes beta-NADH, beta-NADPH, and alpha-NADPH. 

Sequence Annotation

 ACT_SITE 197 197 Proton donor (By similarity).
 BINDING 38 38 FMN (By similarity).
 BINDING 192 192 FMN (By similarity).
 BINDING 192 192 Substrate (By similarity).
 BINDING 195 195 Substrate (By similarity).
 BINDING 244 244 FMN (By similarity).
 BINDING 349 349 FMN (By similarity).
 BINDING 376 376 Substrate (By similarity).
 MOD_RES 353 353 Phosphoserine.
 MOD_RES 379 379 Phosphoserine.  

Keyword

 Complete proteome; Direct protein sequencing; Flavoprotein; FMN; NADP; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 400 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0010181; F:FMN binding; IEA:InterPro.
 GO:0003959; F:NADPH dehydrogenase activity; IDA:SGD.
 GO:0018548; F:pentaerythritol trinitrate reductase activity; IEA:EC.
 GO:0052690; F:trichloro-p-hydroquinone reductive dehalogenase activity; IEA:EC.
 GO:0006915; P:apoptotic process; IMP:SGD. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR001155; OxRdtase_FMN_N. 

Pfam

 PF00724; Oxidored_FMN 

SMART

  

PROSITE

  

PRINTS