UniProt Accession

 SEPT6_HUMAN; Q14141; Q5JTK0; Q969W5; Q96A13; Q96GR1; Q96P86; Q96P87 

Genbank Protein ID

 AF403058; AF403059; AF403060; AF403061; AF403062; AL355348; AC004913; AC005052; BC009291; BC011922; BC036240; D50918 

Genbank Nucleotide ID

 AAK98547.1; AAK98548.1; AAK98549.1; AAK98550.1; AAK98551.1; CAI41426.1; CAI41426.1; CAI41426.1; AAH09291.1; AAH11922.3; AAH36240.1; BAA09477.1 

Protein Name

 Septin-6 

Protein Synonyms/Alias

  

Gene Name

 SEPT6 

Gene Synonyms/Alias

 KIAA0128; SEP2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	MDTLFNTKFEGEPAT	ubiquitination	[1]
185	NIIPIIAKADAISKS	ubiquitination	[1]
191	AKADAISKSELTKFK	ubiquitination	[1]
196	ISKSELTKFKIKITS	acetylation	[2]
196	ISKSELTKFKIKITS	ubiquitination	[1]
249	EELKIGNKMMRARQY	ubiquitination	[1]
273	EAHCDFVKLREMLIR	ubiquitination	[1]
316	KDTDPDSKPFSLQET	ubiquitination	[3]
327	LQETYEAKRNEFLGE	ubiquitination	[3, 4]
362	AELKEAEKELHEKFD	ubiquitination	[1]
367	AEKELHEKFDRLKKL	acetylation	[2]
367	AEKELHEKFDRLKKL	ubiquitination	[1]
386	KKKLEDKKKSLDDEV	ubiquitination	[1]
387	KKLEDKKKSLDDEVN	ubiquitination	[1]
397	DDEVNAFKQRKTAAE	ubiquitination	[1]
400	VNAFKQRKTAAELLQ	ubiquitination	[1]
420	AGGSQTLKRDKEKKN	ubiquitination	[1, 3, 5]
426	LKRDKEKKNNPWLCT	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. 

Sequence Annotation

 NP_BIND 49 56 GTP.
 NP_BIND 185 193 GTP.
 BINDING 104 104 GTP; via amide nitrogen (By similarity).
 BINDING 239 239 GTP; via amide nitrogen and carbonyl
 BINDING 254 254 GTP (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 367 367 N6-acetyllysine.
 MOD_RES 416 416 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; GTP-binding; Host-virus interaction; Kinetochore; Nucleotide-binding; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 434 AA 

Protein Sequence

Gene Ontology

 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0005525; F:GTP binding; TAS:UniProtKB.
 GO:0000910; P:cytokinesis; TAS:UniProtKB.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin. 

Pfam

 PF00735; Septin 

SMART

  

PROSITE

  

PRINTS