CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037513
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Signal peptidase complex subunit 2 
Protein Synonyms/Alias
  
Gene Name
 SPCS2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
88KWDGSAVKNSLDDSAubiquitination[1, 2]
102AKKVLLEKYKYVENFubiquitination[2]
177IFLVAHRKDPTGMDPubiquitination[2]
195WQLSSSLKRFDDKYTubiquitination[1, 2, 3, 4]
200SLKRFDDKYTLKLTFacetylation[5, 6]
200SLKRFDDKYTLKLTFubiquitination[2]
222QREAEFTKSIAKFFDacetylation[5, 6, 7]
222QREAEFTKSIAKFFDubiquitination[1, 2, 3, 4]
226EFTKSIAKFFDHSGTubiquitination[2, 3, 8]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [7] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [8] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 257 AA 
Protein Sequence
MAAAAVQGGR SGGSGGCSGA GGASNCGTGS GRSGLLDKRQ ALTILPRLDS SSWAQAVLPP 60
QPPKYLGWQW KIDDKPVKID KWDGSAVKNS LDDSAKKVLL EKYKYVENFG LIDGRLTICT 120
ISCFFAIVAL IWDYMHPFPE SKPVLALCVI SYFVMMGILT IYTSYKEKSI FLVAHRKDPT 180
GMDPDDIWQL SSSLKRFDDK YTLKLTFISG RTKQQREAEF TKSIAKFFDH SGTLVMDAYE 240
PEISRLHDSL AIERKIK 257 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005787; C:signal peptidase complex; IEA:InterPro.
 GO:0008233; F:peptidase activity; IEA:InterPro.
 GO:0006465; P:signal peptide processing; IEA:InterPro. 
Interpro
 IPR009582; SigPept_cplx_su2. 
Pfam
 PF06703; SPC25 
SMART
  
PROSITE
  
PRINTS