| Tag | Content |
|---|
| CPLM ID | CPLM-021309 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein kinase TAO3 |
Protein Synonyms/Alias | Cutaneous T-cell lymphoma-associated antigen HD-CL-09; CTCL-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; JNK/SAPK-inhibitory kinase; Jun kinase-inhibitory kinase; Kinase from chicken homolog A; hKFC-A; Thousand and one amino acid protein 3 |
Gene Name | TAOK3 |
Gene Synonyms/Alias | DPK; JIK; KDS; MAP3K18 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 260 | FVDYCLQKIPQERPT | ubiquitination | [1] | | 642 | LNKKRTQKEMEHAML | ubiquitination | [1] | | 817 | NAYQSKIKMQTEAQH | ubiquitination | [1] | | 855 | EELAALQKERSERIK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). |
Sequence Annotation | DOMAIN 24 277 Protein kinase.
NP_BIND 30 38 ATP (By similarity).
ACT_SITE 147 147 Proton acceptor (By similarity).
BINDING 53 53 ATP (By similarity).
MOD_RES 324 324 Phosphoserine; by ATM.
MOD_RES 331 331 Phosphoserine.
MOD_RES 346 346 Phosphoserine (By similarity).
MOD_RES 349 349 Phosphoserine (By similarity).
MOD_RES 442 442 Phosphoserine. |
Keyword | ATP-binding; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; DNA damage; DNA repair; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 898 AA |
Protein Sequence | MRKGVLKDPE IADLFYKDDP EELFIGLHEI GHGSFGAVYF ATNAHTSEVV AIKKMSYSGK 60
QTHEKWQDIL KEVKFLRQLK HPNTIEYKGC YLKEHTAWLV MEYCLGSASD LLEVHKKPLQ 120
EVEIAAITHG ALHGLAYLHS HALIHRDIKA GNILLTEPGQ VKLADFGSAS MASPANSFVG 180
TPYWMAPEVI LAMDEGQYDG KVDIWSLGIT CIELAERKPP LFNMNAMSAL YHIAQNDSPT 240
LQSNEWTDSF RRFVDYCLQK IPQERPTSAE LLRHDFVRRD RPLRVLIDLI QRTKDAVREL 300
DNLQYRKMKK ILFQETRNGP LNESQEDEED SEHGTSLNRE MDSLGSNHSI PSMSVSTGSQ 360
SSSVNSMQEV MDESSSELVM MHDDESTINS SSSVVHKKDH VFIRDEAGHG DPRPEPRPTQ 420
SVQSQALHYR NRERFATIKS ASLVTRQIHE HEQENELREQ MSGYKRMRRQ HQKQLIALEN 480
KLKAEMDEHR LKLQKEVETH ANNSSIELEK LAKKQVAIIE KEAKVAAADE KKFQQQILAQ 540
QKKDLTTFLE SQKKQYKICK EKIKEEMNED HSTPKKEKQE RISKHKENLQ HTQAEEEAHL 600
LTQQRLYYDK NCRFFKRKIM IKRHEVEQQN IREELNKKRT QKEMEHAMLI RHDESTRELE 660
YRQLHTLQKL RMDLIRLQHQ TELENQLEYN KRRERELHRK HVMELRQQPK NLKAMEMQIK 720
KQFQDTCKVQ TKQYKALKNH QLEVTPKNEH KTILKTLKDE QTRKLAILAE QYEQSINEMM 780
ASQALRLDEA QEAECQALRL QLQQEMELLN AYQSKIKMQT EAQHERELQK LEQRVSLRRA 840
HLEQKIEEEL AALQKERSER IKNLLERQER EIETFDMESL RMGFGNLVTL DFPKEDYR 898 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:HPA. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004860; F:protein kinase inhibitor activity; TAS:ProtInc. GO:0004674; F:protein serine/threonine kinase activity; IDA:HGNC. GO:0006281; P:DNA repair; IEA:UniProtKB-KW. GO:0031572; P:G2 DNA damage checkpoint; IMP:UniProtKB. GO:0000165; P:MAPK cascade; IMP:HGNC. GO:0046329; P:negative regulation of JNK cascade; IDA:HGNC. GO:0046330; P:positive regulation of JNK cascade; IMP:HGNC. GO:0043507; P:positive regulation of JUN kinase activity; IMP:UniProtKB. GO:0046777; P:protein autophosphorylation; IDA:HGNC. |
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