UniProt Accession

 RXT3_YEAST; Q07458; D6VRS3 

Genbank Protein ID

 Z74124; BK006938 

Genbank Nucleotide ID

 CAA98642.1; DAA11783.1 

Protein Name

 Transcriptional regulatory protein RXT3 

Protein Synonyms/Alias

  

Gene Name

 RXT3 

Gene Synonyms/Alias

 YDL076C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
21	ETQSQIYKLQETLLN	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. 

Sequence Annotation

  

Keyword

 Chromatin regulator; Complete proteome; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 294 AA 

Protein Sequence

Gene Ontology

 GO:0033698; C:Rpd3L complex; IDA:SGD.
 GO:0070210; C:Rpd3L-Expanded complex; IDA:SGD.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0016479; P:negative regulation of transcription from RNA polymerase I promoter; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR013951; Histone_deAc_Rxt3. 

Pfam

 PF08642; Rxt3 

SMART

  

PROSITE

  

PRINTS