CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007057
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Casein kinase II subunit beta' 
Protein Synonyms/Alias
 CK II beta' 
Gene Name
 CKB2 
Gene Synonyms/Alias
 YOR039W; OR26.32 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
108QLESDSRKLYGLIHAubiquitination[1]
132QKMYAKYKEADFGRCubiquitination[1]
177CEDLYIPKSSRHSSIubiquitination[1]
216PTKRYVPKIFGFELHacetylation[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919
Functional Description
 Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 258 AA 
Protein Sequence
MGSRSENVGT VTREGSRVEQ DDVLMDDDSD SSEYVDMWID LFLGRKGHEY FCDVDPEYIT 60
DRFNLMNLQK TVSKFSYVVQ YIVDDLDDSI LENMTHARLE QLESDSRKLY GLIHARYIIT 120
IKGLQKMYAK YKEADFGRCP RVYCNLQQLL PVGLHDIPGI DCVKLYCPSC EDLYIPKSSR 180
HSSIDGAYFG TSFPGMFLQA FPDMVPKHPT KRYVPKIFGF ELHKQAQLTR WQELQRLKLV 240
EKLESKDVDL TKSGGFKT 258 
Gene Ontology
 GO:0032545; C:CURI complex; IDA:SGD.
 GO:0005956; C:protein kinase CK2 complex; IDA:SGD.
 GO:0034456; C:UTP-C complex; IDA:SGD.
 GO:0030291; F:protein serine/threonine kinase inhibitor activity; IDA:SGD.
 GO:0006468; P:protein phosphorylation; IDA:SGD.
 GO:0006356; P:regulation of transcription from RNA polymerase I promoter; IDA:SGD.
 GO:0006359; P:regulation of transcription from RNA polymerase III promoter; IDA:SGD.
 GO:0006974; P:response to DNA damage stimulus; IDA:SGD. 
Interpro
 IPR016149; Casein_kin_II_reg-sub_a-hlx.
 IPR016150; Casein_kin_II_reg-sub_b-sht.
 IPR000704; Casein_kinase_II_reg-sub. 
Pfam
 PF01214; CK_II_beta 
SMART
 SM01085; CK_II_beta 
PROSITE
 PS01101; CK2_BETA 
PRINTS
 PR00472; CASNKINASEII.