UniProt Accession

 RL26_HUMAN; P61254; B2R4F0; D3DTR8; Q02877; Q6IPY2 

Genbank Protein ID

 X69392; L07287; AB061829; AK311804; CH471108; CH471108; CH471108; BC071664 

Genbank Nucleotide ID

 CAA49189.1; AAA60279.1; BAB79467.1; BAG34747.1; EAW90053.1; EAW90054.1; EAW90057.1; AAH71664.1 

Protein Name

 60S ribosomal protein L26 

Protein Synonyms/Alias

  

Gene Name

 RPL26 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
2	******MKFNPFVTS	ubiquitination	[1, 2, 3]
13	FVTSDRSKNRKRHFN	acetylation	[4]
28	APSHIRRKIMSSPLS	ubiquitination	[1, 3, 5]
36	IMSSPLSKELRQKYN	ubiquitination	[1, 2, 3, 5]
51	VRSMPIRKDDEVQVV	ubiquitination	[3, 6]
63	QVVRGHYKGQQIGKV	ubiquitination	[6]
69	YKGQQIGKVVQVYRK	ubiquitination	[1, 2, 3, 5, 6]
76	KVVQVYRKKYVIYIE	ubiquitination	[3]
77	VVQVYRKKYVIYIER	acetylation	[7]
77	VVQVYRKKYVIYIER	ubiquitination	[1, 3, 5]
89	IERVQREKANGTTVH	ubiquitination	[3]
103	HVGIHPSKVVITRLK	ubiquitination	[1, 2, 3, 5, 6]
113	ITRLKLDKDRKKILE	ubiquitination	[3]
134	QVGKEKGKYKEETIE	acetylation	[8]
134	QVGKEKGKYKEETIE	ubiquitination	[8]
136	GKEKGKYKEETIEKM	sumoylation	[9]
136	GKEKGKYKEETIEKM	ubiquitination	[3]
142	YKEETIEKMQE****	acetylation	[10, 11]
142	YKEETIEKMQE****	ubiquitination	[3, 6, 8]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [7] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [8] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [9] Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions.
 Lamoliatte F, Bonneil E, Durette C, Caron-Lizotte O, Wildemann D, Zerweck J, Wenschuh H, Thibault P.
 Mol Cell Proteomics. 2013 Jun 7;. [PMID: 23750026]
 [10] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [11] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

 MOD_RES 139 139 Phosphothreonine.  

Keyword

 3D-structure; Complete proteome; Diamond-Blackfan anemia; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 145 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
 GO:0042273; P:ribosomal large subunit biogenesis; IMP:UniProtKB.
 GO:0006364; P:rRNA processing; IMP:UniProtKB.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006414; P:translational elongation; TAS:Reactome.
 GO:0006413; P:translational initiation; TAS:Reactome.
 GO:0006415; P:translational termination; TAS:Reactome.
 GO:0019083; P:viral transcription; TAS:Reactome. 

Interpro

 IPR005824; KOW.
 IPR014722; Rib_L2_dom2.
 IPR005825; Ribosomal_L24/26_CS.
 IPR005756; Ribosomal_L26/L24P_euk/arc.
 IPR008991; Translation_prot_SH3-like. 

Pfam

 PF00467; KOW 

SMART

 SM00739; KOW 

PROSITE

 PS01108; RIBOSOMAL_L24 

PRINTS