CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023272
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein PLAGL2 
Protein Synonyms/Alias
 Pleiomorphic adenoma-like protein 2 
Gene Name
 PLAGL2 
Gene Synonyms/Alias
 KIAA0198 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
139CGKNYNTKLGYRRHLubiquitination[1]
248SHSQELLKIKTEPVDacetylation[2]
248SHSQELLKIKTEPVDubiquitination[3]
250SQELLKIKTEPVDMLacetylation[4]
250SQELLKIKTEPVDMLsumoylation[5]
269CSSTVSVKEELSPVLacetylation[4]
269CSSTVSVKEELSPVLsumoylation[5]
353STSYLPDKLPKVEVDubiquitination[1, 3]
356YLPDKLPKVEVDSFLacetylation[4]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Tip60 modulates PLAGL2-mediated transactivation by acetylation.
 Ning J, Zheng G, Yang YC.
 J Cell Biochem. 2008 Feb 15;103(3):730-9. [PMID: 17551969]
 [5] Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation.
 Guo Y, Yang MC, Weissler JC, Yang YS.
 Biochem Biophys Res Commun. 2008 Sep 26;374(3):570-5. [PMID: 18655774] 
Functional Description
 Shows weak transcriptional activatory activity. 
Sequence Annotation
 ZN_FING 68 92 C2H2-type 1.
 ZN_FING 98 120 C2H2-type 2.
 ZN_FING 127 149 C2H2-type 3.
 ZN_FING 156 178 C2H2-type 4.
 ZN_FING 191 213 C2H2-type 5.
 ZN_FING 219 242 C2H2-type 6.  
Keyword
 Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 496 AA 
Protein Sequence
MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS NGEKLRPHSL 60
PQPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC MYCDKMFHRK DHLRNHLQTH 120
DPNKEALHCS ECGKNYNTKL GYRRHLAMHA ASSGDLSCKV CLQTFESTQA LLEHLKAHSR 180
RVAGGAKEKK HPCDHCDRRF YTRKDVRRHL VVHTGRKDFL CQYCAQRFGR KDHLTRHVKK 240
SHSQELLKIK TEPVDMLGLL SCSSTVSVKE ELSPVLCMAS RDVMGTKAFP GMLPMGMYGA 300
HIPTMPSTGV PHSLVHNTLP MGMSYPLESS PISSPAQLPP KYQLGSTSYL PDKLPKVEVD 360
SFLAELPGSL SLSSAEPQPA SPQPAAAAAL LDEALLAKSP ANLSEALCAA NVDFSHLLGF 420
LPLNLPPCNP PGATGGLVMG YSQAEAQPLL TTLQAQPQDS PGAGGPLNFG PLHSLPPVFT 480
SGLSSTTLPR FHQAFQ 496 
Gene Ontology
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0034378; P:chylomicron assembly; IBA:RefGenome.
 GO:0006917; P:induction of apoptosis; IBA:RefGenome.
 GO:0006629; P:lipid metabolic process; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS