UniProt Accession

 ST1A1_MOUSE; P52840 

Genbank Protein ID

 L02331 

Genbank Nucleotide ID

  

Protein Name

 Sulfotransferase 1A1 

Protein Synonyms/Alias

 ST1A1; Aryl sulfotransferase; Phenol sulfotransferase; Phenol/aryl sulfotransferase; mSTp1; ST1A4; Sulfokinase 

Gene Name

 Sult1a1 

Gene Synonyms/Alias

 St1a1; Stp; Stp1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
93	PPGLETLKETPAPRI	ubiquitination	[1]
102	TPAPRIIKTHLPLSL	ubiquitination	[1]
118	PQSLLDQKIKVIYVA	ubiquitination	[1]
120	SLLDQKIKVIYVARN	ubiquitination	[1]
129	IYVARNAKDVVVSYY	ubiquitination	[1]
193	YLFYEDMKENPKREI	ubiquitination	[1]
202	NPKREIKKILEFLGR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk (By similarity). 

Sequence Annotation

 NP_BIND 44 49 PAPS (By similarity).
 NP_BIND 223 228 PAPS (By similarity).
 NP_BIND 251 255 PAPS (By similarity).
 REGION 102 104 Substrate binding (By similarity).
 ACT_SITE 104 104 Proton acceptor (By similarity).
 BINDING 126 126 PAPS (By similarity).
 BINDING 134 134 PAPS (By similarity).
 BINDING 189 189 PAPS (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Lipid metabolism; Reference proteome; Steroid metabolism; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 291 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004062; F:aryl sulfotransferase activity; IEA:EC.
 GO:0000166; F:nucleotide binding; IDA:MGI.
 GO:0008146; F:sulfotransferase activity; IDA:MGI.
 GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR000863; Sulfotransferase_dom. 

Pfam

 PF00685; Sulfotransfer_1 

SMART

  

PROSITE

  

PRINTS