CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005419
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucose-induced degradation protein 7 
Protein Synonyms/Alias
  
Gene Name
 GID7 
Gene Synonyms/Alias
 MOH2; YCL039W; YCL311; YCL39W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
269GRLLHLLKQAIKYQQacetylation[1]
725VASNPADKEMFASGGubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Has a role in the negative regulation of gluconeogenesis. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase). 
Sequence Annotation
 REPEAT 167 209 WD 1.
 REPEAT 322 365 WD 2.
 REPEAT 369 408 WD 3.
 REPEAT 540 579 WD 4.
 REPEAT 613 652 WD 5.
 REPEAT 657 696 WD 6.
 REPEAT 710 745 WD 7.  
Keyword
 Complete proteome; Cytoplasm; Nucleus; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 745 AA 
Protein Sequence
MSHTNKIAYV LNNDTEETAS PSSVGCFDKK QLTKLLIHTL KELGYDSAAN QLLLESGGYQ 60
NESNHIQTFF KLIKTGQFHL INWQIVCSLP LAHSSPLRSE WLQRLLIPTP TPATTSLFDH 120
MLLQLQYLQQ LMSSVNSSTC SDAEIATLRN YVEIMILVNR QIFLEFFHPV TNSASHKGPH 180
TALPVLYLRK ILKNFIEIWD SLLVSNDQFL NEENIFNPET TLRELSTYLT NPKLTAQLNL 240
ERDHLIDAIS KYIDPNELVP KGRLLHLLKQ AIKYQQSQDI FNIIDPDDDA SFSSPPHRIN 300
LLQDNFSHDL TVTFQEWKTI QDTTDEIWFL TFSPNGKYLA SATSESSRGY FITVYDVEQD 360
FKIYKTCVSL SQSVLYLMFS PDSRYLVACP FSEDVTIYDM NATSLPDASA TDSFLLYPST 420
RLSPMDSFKL DTTTYPDDTE SSASSSSRPA NANSNQSRVW CCDAFHTAER AGWMVVGSPD 480
REAIVHSLTT KESLFSLKGR TCIALGHDEN ISGRKSIDPA KVLYKPTSSN GNWQYVEDDE 540
TFPRVHDVKI SYDDKYVLLM THQGVIDVYD FSGFPSKEEL SKQTVDPKNF LIPRIARLDV 600
GKNMTCISLP LNTTHQGFHR QQISESQHLV LVSLQDNELQ MWDYKENILI QKYFGQKQQH 660
FIIRSCFAYG NKLVMSGSED GKIYIWDRIR GNLVSVLSGH STVMSNSTKP MGKNCNVVAS 720
NPADKEMFAS GGDDGKIKIW KISRN 745 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0034657; C:GID complex; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0045721; P:negative regulation of gluconeogenesis; IMP:SGD.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:SGD. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS