CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005793
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leiomodin-1 
Protein Synonyms/Alias
 64 kDa autoantigen 1D; 64 kDa autoantigen 1D3; 64 kDa autoantigen D1; Leiomodin, muscle form; Smooth muscle leiomodin; SM-Lmod; Thyroid-associated ophthalmopathy autoantigen 
Gene Name
 LMOD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
308KPSEGPAKVEEEAAPacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 REPEAT 165 180 1.
 REPEAT 181 196 2.
 REPEAT 197 212 3.
 REPEAT 213 228 4.
 REPEAT 229 244 5.
 REPEAT 245 260 6.
 REPEAT 261 276 7.
 REPEAT 277 293 8.
 DOMAIN 574 593 WH2.
 REGION 165 293 8 X approximate tandem repeats.
 REGION 508 527 5 X 4 AA approximate tandem repeats.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 600 AA 
Protein Sequence
MSRVAKYRRQ VSEDPDIDSL LETLSPEEME ELEKELDVVD PDGSVPVGLR QRNQTEKQST 60
GVYNREAMLN FCEKETKKLM QREMSMDESK QVETKTDAKN GEERGRDASK KALGPRRDSD 120
LGKEPKRGGL KKSFSRDRDE AGGKSGEKPK EEKIIRGIDK GRVRAAVDKK EAGKDGRGEE 180
RAVATKKEEE KKGSDRNTGL SRDKDKKREE MKEVAKKEDD EKVKGERRNT DTRKEGEKMK 240
RAGGNTDMKK EDEKVKRGTG NTDTKKDDEK VKKNEPLHEK EAKDDSKTKT PEKQTPSGPT 300
KPSEGPAKVE EEAAPSIFDE PLERVKNNDP EMTEVNVNNS DCITNEILVR FTEALEFNTV 360
VKLFALANTR ADDHVAFAIA IMLKANKTIT SLNLDSNHIT GKGILAIFRA LLQNNTLTEL 420
RFHNQRHICG GKTEMEIAKL LKENTTLLKL GYHFELAGPR MTVTNLLSRN MDKQRQKRLQ 480
EQRQAQEAKG EKKDLLEVPK AGAVAKGSPK PSPQPSPKPS PKNSPKKGGA PAAPPPPPPP 540
LAPPLIMENL KNSLSPATQR KMGDKVLPAQ EKNSRDQLLA AIRSSNLKQL KKVEVPKLLQ 600 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016020; C:membrane; TAS:ProtInc.
 GO:0006936; P:muscle contraction; TAS:Reactome. 
Interpro
 IPR004934; Tropomodulin.
 IPR003124; WH2_dom. 
Pfam
 PF03250; Tropomodulin
 PF02205; WH2 
SMART
 SM00246; WH2 
PROSITE
 PS51082; WH2 
PRINTS