CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001728
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 2B1 
Protein Synonyms/Alias
 CYPIIB1; Cytochrome P450-B; Cytochrome P450b; Cytochrome P450-LM2; Cytochrome P450-PB1; Cytochrome P450-PB2 
Gene Name
 Cyp2b1 
Gene Synonyms/Alias
 Cyp2b-1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
251YIGHIVEKHRATLDPacetylation[1]
384FRGYLLPKNTEVYPIacetylation[1]
422DANGALKKSEAFMPFacetylation[1]
433FMPFSTGKRICLGEGacetylation[1]
473KDIDLTPKESGIGKIacetylation[1]
Reference
 [1] Role of lysine and arginine residues of cytochrome P450 in the interaction between cytochrome P4502B1 and NADPH-cytochrome P450 reductase.
 Shen S, Strobel HW.
 Arch Biochem Biophys. 1993 Jul;304(1):257-65. [PMID: 8323289] 
Functional Description
 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 
Sequence Annotation
 METAL 436 436 Iron (heme axial ligand).
 MOD_RES 128 128 Phosphoserine; by PKA.  
Keyword
 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 491 AA 
Protein Sequence
MEPTILLLLA LLVGFLLLLV RGHPKSRGNF PPGPRPLPLL GNLLQLDRGG LLNSFMQLRE 60
KYGDVFTVHL GPRPVVMLCG TDTIKEALVG QAEDFSGRGT IAVIEPIFKE YGVIFANGER 120
WKALRRFSLA TMRDFGMGKR SVEERIQEEA QCLVEELRKS QGAPLDPTFL FQCITANIIC 180
SIVFGERFDY TDRQFLRLLE LFYRTFSLLS SFSSQVFEFF SGFLKYFPGA HRQISKNLQE 240
ILDYIGHIVE KHRATLDPSA PRDFIDTYLL RMEKEKSNHH TEFHHENLMI SLLSLFFAGT 300
ETSSTTLRYG FLLMLKYPHV AEKVQKEIDQ VIGSHRLPTL DDRSKMPYTD AVIHEIQRFS 360
DLVPIGVPHR VTKDTMFRGY LLPKNTEVYP ILSSALHDPQ YFDHPDSFNP EHFLDANGAL 420
KKSEAFMPFS TGKRICLGEG IARNELFLFF TTILQNFSVS SHLAPKDIDL TPKESGIGKI 480
PPTYQICFSA R 491 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0008395; F:steroid hydroxylase activity; IDA:RGD.
 GO:0017144; P:drug metabolic process; IDA:RGD.
 GO:0051592; P:response to calcium ion; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0032868; P:response to insulin stimulus; IEP:RGD.
 GO:0014070; P:response to organic cyclic compound; IEP:RGD.
 GO:0010477; P:response to sulfur dioxide; IEP:RGD. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008068; Cyt_P450_E_grp-I_CYP2B-like. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR01685; EP450ICYP2B.
 PR00385; P450.