CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041005
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tryptophan--tRNA ligase, cytoplasmic 
Protein Synonyms/Alias
  
Gene Name
 Wars 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
370IFLTDTAKQIKSKVNacetylation[1]
454AEHQARRKAVTEETVubiquitination[2]
462AVTEETVKEFMAPRQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 475 AA 
Protein Sequence
MADMPSGESC TSPLELFNSI AAQGELVRSL KAGNAPKDEI ESAVKMLLSL KMNYKTAMGE 60
EYKAGCPPGN STAGSNGDPD ATKASEDFVD PWTVRTSSAK GIDYDKLIVQ FGSSKIDKEL 120
INRIERATGQ RPHRFLRRGI FFSHRDMNQI LDAYENKKPF YLYTGRGPSS EAMHLGHLVP 180
FIFTKWLQDV FDVPLVIQMS DDEKYLWKDL TLEQAYSYTV ENAKDIIACG FDVNKTFIFS 240
DLEYMGQSPG FYKNVVKIQK HVTFNQVKGI FGFTDSDCIG KISFPAVQAA PSFSNSFPKI 300
FRDRTDIQCL IPCAIDQDPY FRMTRDVAPR IGHPKPALLH STFFPALQGA QTKMSASDPN 360
SSIFLTDTAK QIKSKVNKHA FSGGRDTVEE HRQFGGNCEV DVSFMYLTFF LEDDDSLEQI 420
RKDYTSGAML TGELKKTLID VLQPLIAEHQ ARRKAVTEET VKEFMAPRQL SFHFQ 475 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004830; F:tryptophan-tRNA ligase activity; IEA:InterPro.
 GO:0045765; P:regulation of angiogenesis; IEA:Compara.
 GO:0006436; P:tryptophanyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR001412; aa-tRNA-synth_I_CS.
 IPR002305; aa-tRNA-synth_Ic.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR009068; S15_NS1_RNA-bd.
 IPR002306; Trp-tRNA-ligase.
 IPR000738; WHEP-TRS. 
Pfam
 PF00579; tRNA-synt_1b
 PF00458; WHEP-TRS 
SMART
 SM00991; WHEP-TRS 
PROSITE
 PS00178; AA_TRNA_LIGASE_I
 PS00762; WHEP_TRS_1
 PS51185; WHEP_TRS_2 
PRINTS
 PR01039; TRNASYNTHTRP.