CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041056
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Kmt2c 
Protein Synonyms/Alias
  
Gene Name
 Kmt2c 
Gene Synonyms/Alias
 Mll3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
821TPKIGMGKPAITKRKacetylation[1]
1742SEHEQEWKFRQQMRQacetylation[1]
1762AKIEATQKLEQVKNEacetylation[2, 3, 4]
2006GTSDHFTKPSPRTDAacetylation[2, 3, 4]
2797KTRDQGDKTMVLEDKacetylation[3, 4]
2863TNHSDRGKTALLTTDacetylation[2, 4]
3786ASSLLTQKPEGTLSSacetylation[3]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Methyltransferase; Nucleus; Reference proteome; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4904 AA 
Protein Sequence
MSSEEDRSAE QQQPPPAPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR ARKKPRSRGK 60
STVEDEDSMD GLETTETENI VETEIKEQSV EEDAETEVDS SKQPVSALQR SVSEESANSL 120
VSVGVEAKIS EQLCAFCYCG EKSSLGQGDL KQFRVTPGLT LPWKDQPSNK DIDDNSSGTC 180
EKIQNYAPRK QRGQRKERPP QQSAVSCVSV STQTACEDQA GKLWDELSLV GLPDAIDVQA 240
LFDSTGTCWA HHRCVEWSLG ICQMEEPLLV NVDKAVVSGS TERCAFCKHL GATIKCCEEK 300
CTQMYHYPCA AGAGTFQDFS HFFLLCPEHI DQAPERSKED ANCAVCDSPG DLLDQFFCTT 360
CGQHYHGMCL DIAVTPLKRA GWQCPECKVC QNCKQSGEDS KMLVCDTCDK GYHTFCLQPV 420
MKSVPTNGWK CKNCRICIEC GTRSSTQWHH NCLICDTCYQ QQDNLCPFCG KCYHPELQKD 480
MLHCNMCKRW VHLECDKPTD QELDSQLKED YICMYCKHLG AEIDPLHPGN EVEMPELPTD 540
YASGMEIEGT EDEVVFLEQT VNKDVSDHQC RPGIVPDAVQ VYTEEPQKSN PLESPDTVGL 600
ITSESSDNKM NPDLANEIAH EVDTEKTEML SKGRHVCEED QNEDRMEVTE NIEVLPHQTI 660
VPQEDLLLSE DSEVASKELS PPKSAPETAA PEALLSPHSE RSLSCKEPLL TERVQEEMEQ 720
KENSEFSTGC VDFEMTLAVD SCDKDSSCQG DKYVELPAEE ESTFSSATDL NKADVSSSST 780
LCSDLPSCDM LHGYPPAFNS AAGSIMPTTY ISVTPKIGMG KPAITKRKFS PGRPRSKQGA 840
WSNHNTVSPP SWAPDTSEGR EIFKPRQLSG SAIWSIKVGR GSGFPGKRRP RGAGLSGRGG 900
RGRSKLKSGI GAVVLPGVSA ADISSNKDEE ENSMHNTVVL FSSSDKFTLQ QDMCVVCGSF 960
GQGAEGRLLA CSQCGQCYHP YCVSIKITKV VLSKGWRCLE CTVCEACGKA TDPGRLLLCD 1020
DCDISYHTYC LDPPLQTVPK GGWKCKWCVW CRHCGATSAG LRCEWQNNYT QCAPCASLSS 1080
CPVCCRNYRE EDLILQCRQC DRWMHAVCQN LNTEEEVENV ADIGFDCSMC RPYMPVSNVP 1140
SSDCCDSSLV AQIVTKVKEL DPPKTYTQDG VCLTESGMSQ LQSLTVTAPR RKRTKPKLKL 1200
KIINQNSVAV LQTPPDIQSE HSRDGEMDDS REGELMDCDG KSESSPEREA GDDETKGIEG 1260
TDAIKKRKRK PYRPGIGGFM VRQRSRTGQG KAKRSVVRKD SSGSISEQLP SRDDGWREQL 1320
PDTLVDEPVS VAENTDKIKK RYRKRKNKLE ETFPAYLQEA FFGKDLLDTS RQNKLSVDNL 1380
SEDAAQLSFK TGFLDPSSDP LLSSSSTSAK PGTQGTADDP LADISEVLNT DDDILGIISD 1440
DLAKSVDHSD IGPTTADASS LPQPGVSQSS RPLTEEQLDG ILSPELDKMV TDGAILGKLY 1500
KIPELGGKDV EDLFTAVLSP ATTQPAPLPQ PPPPPQLLPM HNQDVFSRMP LMNGLIGPSP 1560
HLPHNSLPPG SGLGTFPAIA QSPYTDVRDK SPAFNAIASD PNSSWAPTTP SMEGENDTLS 1620
NAQRSTLKWE KEEALGEMAT VAPVLYTNIN FPNLKEEFPD WTTRVKQIAK LWRKASSQER 1680
APYVQKARDN RAALRINKVQ MSNDSMKRQQ QQDSIDPSSR IDSDLFKDPL KQRESEHEQE 1740
WKFRQQMRQK SKQQAKIEAT QKLEQVKNEQ QQQQQQQQQQ QQQQLASQHL LVAPGSDTPS 1800
SGAQSPLTPQ AGNGNVSPAQ TFHKDLFSKH LPGTPASTPS DGVFVKPQPP PPPSTPSRIP 1860
VQESLSQSQN SQPPSPQMFS PGSSHSRPPS PVDPYAKMVG TPRPPPGGHS FPRRNSVTPV 1920
ENCVPLSSVP RPIHMNETSA TRPSPARDLC ASSMTNSDPY AKPPDTPRPM MTDQFSKPFS 1980
LPRSPVISEQ STKGPLTTGT SDHFTKPSPR TDAFQRQRLP DPYAGPSLTP APLGNGPFKT 2040
PLHPPPSQDP YGSVSQTSRR LSVDPYERPA LTPRPVDNFS HSQSNDPYSH PPLTPHPAMT 2100
ESFTHASRAF PQPGTISRSA SQDPYSQPPG TPRPLIDSYS QTSGTARSNP DPYSQPPGTP 2160
RPNTIDPYSQ QPPTPRPSPQ TDMFVSSVAN QRHTDPYTHH LGPPRPGISV PYSQPPAVPR 2220
PRTSEGFTRP SSARPALMPN QDPFLQAAQN RVPGLPGPLI RPPDTCSQTP RPPGPGRIDT 2280
FTHASSSAVR DPYDQPPVTP RPHSESFGTS QVVHDLVDRP VPGSEGNFST SSNLPVSSQG 2340
QQFSSVSQLP GPVPTSGGTD TQNTVNMSQA DTEKLRQRQK LREIILQQQQ QKKIASRQEK 2400
GPQDTAVVPH PVPLPHWQPE SINQAFTRPP PPYPGSTRSP VIPPLGPRYA VFPKDQRGPY 2460
PPEVAGMGMR PHGFRFGFPG AGHGPMPSQD RFHVPQQIQG SGIPPHIRRP MSMEMPRPSN 2520
NPPLNNPVGL PQHFPPQGLP VQQHNILGQA FIELRHRAPD GRSRLPFAAS PSSVIESPSH 2580
PRHGNFLPRP DFPGPRHTDP IRQPSQCLSN QLPVHPNLEQ VPPSQQEQGH PAHQSSIVMR 2640
PLNHPLSGEF SEAPLSTSTP AETSPDNLEI AGQSSAGLEE KLDSDDPSVK ELDVKDLEGV 2700
EVKDLDDEDL ENLNLDTEDG KGDDLDTLDN LETNDPNLDD LLRSGEFDII AYTDPELDLG 2760
DKKSMFNEEL DLNVPIDDKL DNQCASVEPK TRDQGDKTMV LEDKDLPQRK SSVSSEIKTE 2820
ALSPYSKEEI QSEIKNHDDS RGDADTACSQ AASAQTNHSD RGKTALLTTD QDMLEKRCNQ 2880
ENAGPVVSAI QGSTPLPARD VMNSCDITGS TPVLSSLLSN EKCDDSDIRP SGSSPPSLPI 2940
SPSTHGSSLP PTLIVPPSPL LDNTVNSNVT VVPRINHAFS QGVPVNPGFI QGQSSVNHNL 3000
GTGKPTNQTV PLTNQSSTMS GPQQLMIPQT LAQQNRERPL LLEEQPLLLQ DLLDQERQEQ 3060
QQQRQMQAMI RQRSEPFFPN IDFDAITDPI MKAKMVALKG INKVMAQNSL GMPPMVMSRF 3120
PFMGPSVAGT QNNDGQTLVP QAVAQDGSIT HQISRPNPPN FGPGFVNDSQ RKQYEEWLQE 3180
TQQLLQMQQK YLEEQIGAHR KSKKALSAKQ RTAKKAGREF PEEDAEQLKH VTEQQSMVQK 3240
QLEQIRKQQK EHAELIEDYR IKQQQQQQQC ALAPPILMPG VQPQPPLVPG ATSLTMSQPN 3300
FPMVPQQLQH QQHTAVISGH TSPARMPSLP GWQSNSASAH LPLNPPRIQP PIAQLSLKTC 3360
TPAPGTVSSA NPQNGPPPRV EFDDNNPFSE SFQERERKER LREQQERQRV QLMQEVDRQR 3420
ALQQRMEMEQ HCLMGAELAN RTPVSQMPFY GSDRPCDFLQ PPRPLQQSPQ HQQQIGPVLQ 3480
QQNVQQGSVN SPPNQTFMQT NEQRQVGPPS FVPDSPSASG GSPNFHSVKP GHGNLPGSSF 3540
QQSPLRPPFT PILPGTSPVA NSNVPCGQDP AVTQGQNYSG SSQSLIQLYS DIIPEEKGKK 3600
KRTRKKKKDD DAESGKAPST PHSDCAAPLT PGLSETTSTP AVSSPSELPQ QRQQEPVEPV 3660
PVPTPNVSAG QPCIESENKL PNSEFIKETS NQQTHVNAEA DKPSVETPNK TEEIKLEKAE 3720
TQPSQEDTKV EEKTGNKIKD IVAGPVSSIQ CPSHPVGTPT TKGDTGNELL KHLLKNKKAS 3780
SLLTQKPEGT LSSDESSTKD GKLIEKQSPA EGLQTLGAQM QGGFGGGNSQ LPKTDGASEN 3840
KKQRSKRTQR TGEKAAPRSK KRKKDEEEKQ AMYSSSDSFT HLKQQNNLSN PPTPPASLPP 3900
TPPPMACQKM ANGFATTEEL AGKAGVLVSH EVARALGPKP FQLPFRPQDD LLARAIAQGP 3960
KTVDVPASLP TPPHNNHEEL RIQDHYGDRD TPDSFVPSSS PESVVGVEVN KYPDLSLVKE 4020
EPPEPVPSPI IPILPSISGK NSESRRNDIK TEPGTLFFTS PFGSSPNGPR SGLISVAITL 4080
HPTAAENISS VVAAFSDLLH VRIPNSYEVS NAPDVPPMGL VSSHRVNPSL EYRQHLLLRG 4140
PPPGSANPPR LATSYRLKQP NVPFPPTSNG LSGYKDSSHG PAEGASLRPQ WCCHCKVVIL 4200
GSGVRKSCKD LTFVNKGSRE NTKRMEKDIV FCSNNCFILY SSAAQAKNSD NKESLPSLPQ 4260
SPMKEPSKAF HQYSNNISTL DVHCLPQFQE KVSPPASPPI SFPPAFEAAK VESKPDELKV 4320
TVKLKPRLRT VPVGLEDCRP LNKKWRGMKW KKWSIHIVIP KGTFKPPCED EIDEFLKKLG 4380
TCLKPDPVPK DCRKCCFCHE EGDGLTDGPA RLLNLDLDLW VHLNCALWST EVYETQAGAL 4440
INVELALRRG LQMKCVFCHK TGATSGCHRF RCTNIYHFTC ATKAQCMFFK DKTMLCPMHK 4500
PKGIHEQQLS YFAVFRRVYV QRDEVRQIAS IVQRGERDHT FRVGSLIFHT IGQLLPQQMQ 4560
AFHSPKALFP VGYEASRLYW STRYANRRCR YLCSIEEKDG RPVFVIRIVE QGHEDLVLSD 4620
SSPKDVWDKI LEPVACVRKK SEMLQLFPAY LKGEDLFGLT VSAVARIAES LPGVEACENY 4680
TFRYGRNPLM ELPLAVNPTG CARSEPKMSA HVKRFVLRPH TLNSTSTSKS FQSTVTGELN 4740
APYSKQFVHS KSSQYRRMKT EWKSNVYLAR SRIQGLGLYA ARDIEKHTMV IEYIGTIIRN 4800
EVANRKEKLY ESQNRGVYMF RMDNDHVIDA TLTGGPARYI NHSCAPNCVA EVVTFERGHK 4860
IIISSNRRIQ KGEELCYDYK FDFEDDQHKI PCHCGAVNCR KWMN 4904 
Gene Ontology
 GO:0035097; C:histone methyltransferase complex; ISO:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0042800; F:histone methyltransferase activity (H3-K4 specific); ISO:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR003889; FYrich_C.
 IPR003888; FYrich_N.
 IPR009071; HMG_box_dom.
 IPR000637; HMGI/Y_DNA-bd_CS.
 IPR003616; Post-SET_dom.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR001214; SET_dom.
 IPR001594; Znf_DHHC_palmitoyltrfase.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF05965; FYRC
 PF05964; FYRN
 PF00628; PHD
 PF00856; SET 
SMART
 SM00384; AT_hook
 SM00109; C1
 SM00542; FYRC
 SM00541; FYRN
 SM00398; HMG
 SM00249; PHD
 SM00508; PostSET
 SM00184; RING
 SM00317; SET 
PROSITE
 PS51543; FYRC
 PS51542; FYRN
 PS00354; HMGI_Y
 PS50868; POST_SET
 PS50280; SET
 PS50216; ZF_DHHC
 PS50016; ZF_PHD_2
 PS50089; ZF_RING_2 
PRINTS