CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011546
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prolow-density lipoprotein receptor-related protein 1 
Protein Synonyms/Alias
 LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD91; Low-density lipoprotein receptor-related protein 1 85 kDa subunit; LRP-85; Low-density lipoprotein receptor-related protein 1 515 kDa subunit; LRP-515; Low-density lipoprotein receptor-related protein 1 intracellular domain; LRPICD 
Gene Name
 LRP1 
Gene Synonyms/Alias
 A2MR; APR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
458QVVTRVDKGGALHIYmethylation[1]
2143TGIGVQLKDIKVFNRubiquitination[2]
2146GVQLKDIKVFNRDRQubiquitination[2]
3528GDGSDEPKEECDERTubiquitination[2]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. 
Sequence Annotation
 DOMAIN 25 66 LDL-receptor class A 1.
 DOMAIN 70 110 LDL-receptor class A 2.
 DOMAIN 111 149 EGF-like 1.
 DOMAIN 150 189 EGF-like 2; calcium-binding (Potential).
 REPEAT 292 334 LDL-receptor class B 1.
 REPEAT 335 378 LDL-receptor class B 2.
 REPEAT 379 422 LDL-receptor class B 3.
 DOMAIN 474 520 EGF-like 3.
 REPEAT 571 613 LDL-receptor class B 4.
 REPEAT 614 659 LDL-receptor class B 5.
 REPEAT 660 710 LDL-receptor class B 6.
 REPEAT 711 754 LDL-receptor class B 7.
 DOMAIN 803 843 EGF-like 4.
 DOMAIN 852 892 LDL-receptor class A 3.
 DOMAIN 893 933 LDL-receptor class A 4.
 DOMAIN 934 973 LDL-receptor class A 5.
 DOMAIN 974 1013 LDL-receptor class A 6.
 DOMAIN 1013 1053 LDL-receptor class A 7.
 DOMAIN 1060 1099 LDL-receptor class A 8.
 DOMAIN 1102 1142 LDL-receptor class A 9.
 DOMAIN 1143 1182 LDL-receptor class A 10.
 DOMAIN 1183 1222 EGF-like 5.
 DOMAIN 1223 1262 EGF-like 6.
 REPEAT 1309 1355 LDL-receptor class B 8.
 REPEAT 1356 1398 LDL-receptor class B 9.
 REPEAT 1399 1445 LDL-receptor class B 10.
 REPEAT 1446 1490 LDL-receptor class B 11.
 REPEAT 1491 1531 LDL-receptor class B 12.
 DOMAIN 1536 1579 EGF-like 7.
 REPEAT 1627 1669 LDL-receptor class B 13.
 REPEAT 1670 1713 LDL-receptor class B 14.
 REPEAT 1714 1753 LDL-receptor class B 15.
 REPEAT 1754 1798 LDL-receptor class B 16.
 DOMAIN 1846 1887 EGF-like 8.
 REPEAT 1934 1976 LDL-receptor class B 17.
 REPEAT 1977 2019 LDL-receptor class B 18.
 REPEAT 2020 2063 LDL-receptor class B 19.
 REPEAT 2064 2107 LDL-receptor class B 20.
 DOMAIN 2155 2195 EGF-like 9.
 REPEAT 2253 2294 LDL-receptor class B 21.
 REPEAT 2295 2343 LDL-receptor class B 22.
 REPEAT 2344 2388 LDL-receptor class B 23.
 REPEAT 2389 2431 LDL-receptor class B 24.
 REPEAT 2432 2473 LDL-receptor class B 25.
 DOMAIN 2478 2518 EGF-like 10.
 DOMAIN 2522 2563 LDL-receptor class A 11.
 DOMAIN 2564 2602 LDL-receptor class A 12.
 DOMAIN 2603 2641 LDL-receptor class A 13.
 DOMAIN 2642 2690 LDL-receptor class A 14.
 DOMAIN 2694 2732 LDL-receptor class A 15.
 DOMAIN 2732 2771 LDL-receptor class A 16.
 DOMAIN 2772 2814 LDL-receptor class A 17.
 DOMAIN 2816 2855 LDL-receptor class A 18.
 DOMAIN 2856 2899 LDL-receptor class A 19.
 DOMAIN 2902 2940 LDL-receptor class A 20.
 DOMAIN 2941 2981 EGF-like 11.
 DOMAIN 2982 3022 EGF-like 12; calcium-binding (Potential).
 REPEAT 3069 3113 LDL-receptor class B 26.
 REPEAT 3114 3156 LDL-receptor class B 27.
 REPEAT 3157 3200 LDL-receptor class B 28.
 REPEAT 3201 3243 LDL-receptor class B 29.
 REPEAT 3244 3284 LDL-receptor class B 30.
 DOMAIN 3290 3331 EGF-like 13.
 DOMAIN 3332 3371 LDL-receptor class A 21.
 DOMAIN 3372 3410 LDL-receptor class A 22.
 DOMAIN 3411 3450 LDL-receptor class A 23.
 DOMAIN 3451 3491 LDL-receptor class A 24.
 DOMAIN 3492 3533 LDL-receptor class A 25.
 DOMAIN 3534 3572 LDL-receptor class A 26.
 DOMAIN 3573 3611 LDL-receptor class A 27.
 DOMAIN 3611 3649 LDL-receptor class A 28.
 DOMAIN 3652 3692 LDL-receptor class A 29.
 DOMAIN 3693 3733 LDL-receptor class A 30.
 DOMAIN 3739 3778 LDL-receptor class A 31.
 DOMAIN 3781 3823 EGF-like 14.
 DOMAIN 3824 3861 EGF-like 15.
 REPEAT 3912 3954 LDL-receptor class B 31.
 REPEAT 3970 4012 LDL-receptor class B 32.
 REPEAT 4013 4056 LDL-receptor class B 33.
 REPEAT 4057 4101 LDL-receptor class B 34.
 DOMAIN 4147 4183 EGF-like 16.
 DOMAIN 4196 4232 EGF-like 17.
 DOMAIN 4232 4268 EGF-like 18.
 DOMAIN 4268 4304 EGF-like 19.
 DOMAIN 4304 4340 EGF-like 20.
 DOMAIN 4340 4375 EGF-like 21.
 DOMAIN 4373 4409 EGF-like 22.
 REGION 4445 4544 Interaction with MAFB (By similarity).
 MOTIF 3940 3943 Recognition site for proteolytical
 MOTIF 4502 4507 NPXY motif.
 METAL 871 871 Calcium 1; via carbonyl oxygen.
 METAL 874 874 Calcium 1.
 METAL 876 876 Calcium 1; via carbonyl oxygen.
 METAL 878 878 Calcium 1.
 METAL 884 884 Calcium 1.
 METAL 885 885 Calcium 1.
 METAL 1032 1032 Calcium 2; via carbonyl oxygen.
 METAL 1035 1035 Calcium 2.
 METAL 1037 1037 Calcium 2; via carbonyl oxygen.
 METAL 1039 1039 Calcium 2.
 METAL 1045 1045 Calcium 2.
 METAL 1046 1046 Calcium 2.
 METAL 1080 1080 Calcium 3; via carbonyl oxygen.
 METAL 1083 1083 Calcium 3.
 METAL 1085 1085 Calcium 3; via carbonyl oxygen.
 METAL 1087 1087 Calcium 3.
 METAL 1093 1093 Calcium 3.
 METAL 1094 1094 Calcium 3.
 MOD_RES 4460 4460 Phosphothreonine (Probable).
 MOD_RES 4507 4507 Phosphotyrosine.
 MOD_RES 4517 4517 Phosphoserine (Probable).
 MOD_RES 4520 4520 Phosphoserine (Probable).
 MOD_RES 4523 4523 Phosphoserine (Probable).
 MOD_RES 4524 4524 Phosphothreonine (By similarity).
 CARBOHYD 114 114 N-linked (GlcNAc...) (Potential).
 CARBOHYD 136 136 N-linked (GlcNAc...) (Potential).
 CARBOHYD 185 185 N-linked (GlcNAc...) (Potential).
 CARBOHYD 239 239 N-linked (GlcNAc...) (Potential).
 CARBOHYD 274 274 N-linked (GlcNAc...) (Potential).
 CARBOHYD 357 357 N-linked (GlcNAc...) (Potential).
 CARBOHYD 446 446 N-linked (GlcNAc...).
 CARBOHYD 729 729 N-linked (GlcNAc...).
 CARBOHYD 928 928 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1050 1050 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1154 1154 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1155 1155 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1195 1195 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1218 1218 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1511 1511 N-linked (GlcNAc...).
 CARBOHYD 1558 1558 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1575 1575 N-linked (GlcNAc...).
 CARBOHYD 1616 1616 N-linked (GlcNAc...).
 CARBOHYD 1645 1645 N-linked (GlcNAc...).
 CARBOHYD 1723 1723 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1733 1733 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1763 1763 N-linked (GlcNAc...).
 CARBOHYD 1825 1825 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1933 1933 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1995 1995 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2048 2048 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2117 2117 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2127 2127 N-linked (GlcNAc...).
 CARBOHYD 2472 2472 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2502 2502 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2521 2521 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2539 2539 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2601 2601 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2620 2620 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2638 2638 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2815 2815 N-linked (GlcNAc...).
 CARBOHYD 2905 2905 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3048 3048 N-linked (GlcNAc...).
 CARBOHYD 3089 3089 N-linked (GlcNAc...).
 CARBOHYD 3264 3264 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3333 3333 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3488 3488 N-linked (GlcNAc...).
 CARBOHYD 3662 3662 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3788 3788 N-linked (GlcNAc...).
 CARBOHYD 3839 3839 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3953 3953 N-linked (GlcNAc...).
 CARBOHYD 4075 4075 N-linked (GlcNAc...).
 CARBOHYD 4125 4125 N-linked (GlcNAc...).
 CARBOHYD 4179 4179 N-linked (GlcNAc...) (Potential).
 CARBOHYD 4278 4278 N-linked (GlcNAc...) (Potential).
 CARBOHYD 4279 4279 N-linked (GlcNAc...) (Potential).
 CARBOHYD 4364 4364 N-linked (GlcNAc...) (Potential).
 DISULFID 27 40 By similarity.
 DISULFID 34 53 By similarity.
 DISULFID 47 64 By similarity.
 DISULFID 72 85 By similarity.
 DISULFID 79 98 By similarity.
 DISULFID 92 108 By similarity.
 DISULFID 115 124 By similarity.
 DISULFID 120 133 By similarity.
 DISULFID 135 148 By similarity.
 DISULFID 154 164 By similarity.
 DISULFID 160 173 By similarity.
 DISULFID 175 188 By similarity.
 DISULFID 478 493 By similarity.
 DISULFID 489 504 By similarity.
 DISULFID 506 519 By similarity.
 DISULFID 807 818 By similarity.
 DISULFID 814 827 By similarity.
 DISULFID 829 842 By similarity.
 DISULFID 854 866
 DISULFID 861 879
 DISULFID 873 890
 DISULFID 895 907 By similarity.
 DISULFID 902 920 By similarity.
 DISULFID 914 931 By similarity.
 DISULFID 936 948
 DISULFID 943 961
 DISULFID 955 971
 DISULFID 976 989
 DISULFID 984 1002
 DISULFID 996 1011
 DISULFID 1015 1027
 DISULFID 1022 1040
 DISULFID 1034 1051
 DISULFID 1062 1075
 DISULFID 1069 1088
 DISULFID 1082 1097
 DISULFID 1104 1118 By similarity.
 DISULFID 1112 1131 By similarity.
 DISULFID 1125 1140 By similarity.
 DISULFID 1145 1159 By similarity.
 DISULFID 1152 1172 By similarity.
 DISULFID 1166 1182 By similarity.
 DISULFID 1185 1196 By similarity.
 DISULFID 1192 1206 By similarity.
 DISULFID 1208 1221 By similarity.
 DISULFID 1227 1237 By similarity.
 DISULFID 1233 1246 By similarity.
 DISULFID 1248 1261 By similarity.
 DISULFID 1540 1553 By similarity.
 DISULFID 1549 1563 By similarity.
 DISULFID 1565 1578 By similarity.
 DISULFID 1850 1861 By similarity.
 DISULFID 1857 1871 By similarity.
 DISULFID 1873 1886 By similarity.
 DISULFID 2159 2170 By similarity.
 DISULFID 2166 2180 By similarity.
 DISULFID 2182 2194 By similarity.
 DISULFID 2482 2493 By similarity.
 DISULFID 2489 2503 By similarity.
 DISULFID 2505 2517 By similarity.
 DISULFID 2524 2537 By similarity.
 DISULFID 2532 2550 By similarity.
 DISULFID 2544 2561 By similarity.
 DISULFID 2566 2578 By similarity.
 DISULFID 2573 2591 By similarity.
 DISULFID 2585 2600 By similarity.
 DISULFID 2605 2617 By similarity.
 DISULFID 2612 2630 By similarity.
 DISULFID 2624 2639 By similarity.
 DISULFID 2644 2666 By similarity.
 DISULFID 2660 2679 By similarity.
 DISULFID 2673 2688 By similarity.
 DISULFID 2696 2708 By similarity.
 DISULFID 2703 2721 By similarity.
 DISULFID 2715 2730 By similarity.
 DISULFID 2734 2746 By similarity.
 DISULFID 2741 2759 By similarity.
 DISULFID 2753 2769 By similarity.
 DISULFID 2774 2787 By similarity.
 DISULFID 2781 2800 By similarity.
 DISULFID 2794 2812 By similarity.
 DISULFID 2818 2830 By similarity.
 DISULFID 2825 2843 By similarity.
 DISULFID 2837 2853 By similarity.
 DISULFID 2858 2870 By similarity.
 DISULFID 2865 2884 By similarity.
 DISULFID 2878 2897 By similarity.
 DISULFID 2904 2917 By similarity.
 DISULFID 2912 2930 By similarity.
 DISULFID 2924 2939 By similarity.
 DISULFID 2944 2956 By similarity.
 DISULFID 2952 2965 By similarity.
 DISULFID 2967 2980 By similarity.
 DISULFID 2986 2996 By similarity.
 DISULFID 2992 3005 By similarity.
 DISULFID 3007 3021 By similarity.
 DISULFID 3294 3305 By similarity.
 DISULFID 3301 3315 By similarity.
 DISULFID 3317 3330 By similarity.
 DISULFID 3334 3346 By similarity.
 DISULFID 3341 3359 By similarity.
 DISULFID 3353 3369 By similarity.
 DISULFID 3374 3386 By similarity.
 DISULFID 3381 3399 By similarity.
 DISULFID 3393 3408 By similarity.
 DISULFID 3413 3426 By similarity.
 DISULFID 3420 3439 By similarity.
 DISULFID 3433 3448 By similarity.
 DISULFID 3453 3466 By similarity.
 DISULFID 3460 3479 By similarity.
 DISULFID 3473 3489 By similarity.
 DISULFID 3494 3507 By similarity.
 DISULFID 3501 3520 By similarity.
 DISULFID 3514 3531 By similarity.
 DISULFID 3536 3548 By similarity.
 DISULFID 3543 3561 By similarity.
 DISULFID 3555 3570 By similarity.
 DISULFID 3575 3587 By similarity.
 DISULFID 3582 3600 By similarity.
 DISULFID 3594 3609 By similarity.
 DISULFID 3613 3625 By similarity.
 DISULFID 3620 3638 By similarity.
 DISULFID 3632 3647 By similarity.
 DISULFID 3654 3666 By similarity.
 DISULFID 3661 3679 By similarity.
 DISULFID 3673 3690 By similarity.
 DISULFID 3695 3709 By similarity.
 DISULFID 3703 3722 By similarity.
 DISULFID 3716 3731 By similarity.
 DISULFID 3741 3754 By similarity.
 DISULFID 3749 3767 By similarity.
 DISULFID 3761 3776 By similarity.
 DISULFID 3785 3798 By similarity.
 DISULFID 3792 3807 By similarity.
 DISULFID 3809 3822 By similarity.
 DISULFID 3828 3838 By similarity.
 DISULFID 3834 3847 By similarity.
 DISULFID 3849 3860 By similarity.
 DISULFID 4151 4160 By similarity.
 DISULFID 4156 4169 By similarity.
 DISULFID 4171 4182 By similarity.
 DISULFID 4200 4210 By similarity.
 DISULFID 4204 4220 By similarity.
 DISULFID 4222 4231 By similarity.
 DISULFID 4236 4246 By similarity.
 DISULFID 4240 4256 By similarity.
 DISULFID 4258 4267 By similarity.
 DISULFID 4272 4282 By similarity.
 DISULFID 4276 4292 By similarity.
 DISULFID 4294 4303 By similarity.
 DISULFID 4308 4318 By similarity.
 DISULFID 4312 4328 By similarity.
 DISULFID 4330 4339 By similarity.
 DISULFID 4344 4352 By similarity.
 DISULFID 4347 4363 By similarity.
 DISULFID 4365 4374 By similarity.
 DISULFID 4377 4387 By similarity.
 DISULFID 4381 4397 By similarity.
 DISULFID 4399 4408 By similarity.  
Keyword
 3D-structure; Calcium; Cell membrane; Coated pit; Complete proteome; Cytoplasm; Developmental protein; Direct protein sequencing; Disulfide bond; EGF-like domain; Endocytosis; Glycoprotein; Membrane; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4544 AA 
Protein Sequence
MLTPPLLLLL PLLSALVAAA IDAPKTCSPK QFACRDQITC ISKGWRCDGE RDCPDGSDEA 60
PEICPQSKAQ RCQPNEHNCL GTELCVPMSR LCNGVQDCMD GSDEGPHCRE LQGNCSRLGC 120
QHHCVPTLDG PTCYCNSSFQ LQADGKTCKD FDECSVYGTC SQLCTNTDGS FICGCVEGYL 180
LQPDNRSCKA KNEPVDRPPV LLIANSQNIL ATYLSGAQVS TITPTSTRQT TAMDFSYANE 240
TVCWVHVGDS AAQTQLKCAR MPGLKGFVDE HTINISLSLH HVEQMAIDWL TGNFYFVDDI 300
DDRIFVCNRN GDTCVTLLDL ELYNPKGIAL DPAMGKVFFT DYGQIPKVER CDMDGQNRTK 360
LVDSKIVFPH GITLDLVSRL VYWADAYLDY IEVVDYEGKG RQTIIQGILI EHLYGLTVFE 420
NYLYATNSDN ANAQQKTSVI RVNRFNSTEY QVVTRVDKGG ALHIYHQRRQ PRVRSHACEN 480
DQYGKPGGCS DICLLANSHK ARTCRCRSGF SLGSDGKSCK KPEHELFLVY GKGRPGIIRG 540
MDMGAKVPDE HMIPIENLMN PRALDFHAET GFIYFADTTS YLIGRQKIDG TERETILKDG 600
IHNVEGVAVD WMGDNLYWTD DGPKKTISVA RLEKAAQTRK TLIEGKMTHP RAIVVDPLNG 660
WMYWTDWEED PKDSRRGRLE RAWMDGSHRD IFVTSKTVLW PNGLSLDIPA GRLYWVDAFY 720
DRIETILLNG TDRKIVYEGP ELNHAFGLCH HGNYLFWTEY RSGSVYRLER GVGGAPPTVT 780
LLRSERPPIF EIRMYDAQQQ QVGTNKCRVN NGGCSSLCLA TPGSRQCACA EDQVLDADGV 840
TCLANPSYVP PPQCQPGEFA CANSRCIQER WKCDGDNDCL DNSDEAPALC HQHTCPSDRF 900
KCENNRCIPN RWLCDGDNDC GNSEDESNAT CSARTCPPNQ FSCASGRCIP ISWTCDLDDD 960
CGDRSDESAS CAYPTCFPLT QFTCNNGRCI NINWRCDNDN DCGDNSDEAG CSHSCSSTQF 1020
KCNSGRCIPE HWTCDGDNDC GDYSDETHAN CTNQATRPPG GCHTDEFQCR LDGLCIPLRW 1080
RCDGDTDCMD SSDEKSCEGV THVCDPSVKF GCKDSARCIS KAWVCDGDND CEDNSDEENC 1140
ESLACRPPSH PCANNTSVCL PPDKLCDGND DCGDGSDEGE LCDQCSLNNG GCSHNCSVAP 1200
GEGIVCSCPL GMELGPDNHT CQIQSYCAKH LKCSQKCDQN KFSVKCSCYE GWVLEPDGES 1260
CRSLDPFKPF IIFSNRHEIR RIDLHKGDYS VLVPGLRNTI ALDFHLSQSA LYWTDVVEDK 1320
IYRGKLLDNG ALTSFEVVIQ YGLATPEGLA VDWIAGNIYW VESNLDQIEV AKLDGTLRTT 1380
LLAGDIEHPR AIALDPRDGI LFWTDWDASL PRIEAASMSG AGRRTVHRET GSGGWPNGLT 1440
VDYLEKRILW IDARSDAIYS ARYDGSGHME VLRGHEFLSH PFAVTLYGGE VYWTDWRTNT 1500
LAKANKWTGH NVTVVQRTNT QPFDLQVYHP SRQPMAPNPC EANGGQGPCS HLCLINYNRT 1560
VSCACPHLMK LHKDNTTCYE FKKFLLYARQ MEIRGVDLDA PYYNYIISFT VPDIDNVTVL 1620
DYDAREQRVY WSDVRTQAIK RAFINGTGVE TVVSADLPNA HGLAVDWVSR NLFWTSYDTN 1680
KKQINVARLD GSFKNAVVQG LEQPHGLVVH PLRGKLYWTD GDNISMANMD GSNRTLLFSG 1740
QKGPVGLAID FPESKLYWIS SGNHTINRCN LDGSGLEVID AMRSQLGKAT ALAIMGDKLW 1800
WADQVSEKMG TCSKADGSGS VVLRNSTTLV MHMKVYDESI QLDHKGTNPC SVNNGDCSQL 1860
CLPTSETTRS CMCTAGYSLR SGQQACEGVG SFLLYSVHEG IRGIPLDPND KSDALVPVSG 1920
TSLAVGIDFH AENDTIYWVD MGLSTISRAK RDQTWREDVV TNGIGRVEGI AVDWIAGNIY 1980
WTDQGFDVIE VARLNGSFRY VVISQGLDKP RAITVHPEKG YLFWTEWGQY PRIERSRLDG 2040
TERVVLVNVS ISWPNGISVD YQDGKLYWCD ARTDKIERID LETGENREVV LSSNNMDMFS 2100
VSVFEDFIYW SDRTHANGSI KRGSKDNATD SVPLRTGIGV QLKDIKVFNR DRQKGTNVCA 2160
VANGGCQQLC LYRGRGQRAC ACAHGMLAED GASCREYAGY LLYSERTILK SIHLSDERNL 2220
NAPVQPFEDP EHMKNVIALA FDYRAGTSPG TPNRIFFSDI HFGNIQQIND DGSRRITIVE 2280
NVGSVEGLAY HRGWDTLYWT SYTTSTITRH TVDQTRPGAF ERETVITMSG DDHPRAFVLD 2340
ECQNLMFWTN WNEQHPSIMR AALSGANVLT LIEKDIRTPN GLAIDHRAEK LYFSDATLDK 2400
IERCEYDGSH RYVILKSEPV HPFGLAVYGE HIFWTDWVRR AVQRANKHVG SNMKLLRVDI 2460
PQQPMGIIAV ANDTNSCELS PCRINNGGCQ DLCLLTHQGH VNCSCRGGRI LQDDLTCRAV 2520
NSSCRAQDEF ECANGECINF SLTCDGVPHC KDKSDEKPSY CNSRRCKKTF RQCSNGRCVS 2580
NMLWCNGADD CGDGSDEIPC NKTACGVGEF RCRDGTCIGN SSRCNQFVDC EDASDEMNCS 2640
ATDCSSYFRL GVKGVLFQPC ERTSLCYAPS WVCDGANDCG DYSDERDCPG VKRPRCPLNY 2700
FACPSGRCIP MSWTCDKEDD CEHGEDETHC NKFCSEAQFE CQNHRCISKQ WLCDGSDDCG 2760
DGSDEAAHCE GKTCGPSSFS CPGTHVCVPE RWLCDGDKDC ADGADESIAA GCLYNSTCDD 2820
REFMCQNRQC IPKHFVCDHD RDCADGSDES PECEYPTCGP SEFRCANGRC LSSRQWECDG 2880
ENDCHDQSDE APKNPHCTSQ EHKCNASSQF LCSSGRCVAE ALLCNGQDDC GDSSDERGCH 2940
INECLSRKLS GCSQDCEDLK IGFKCRCRPG FRLKDDGRTC ADVDECSTTF PCSQRCINTH 3000
GSYKCLCVEG YAPRGGDPHS CKAVTDEEPF LIFANRYYLR KLNLDGSNYT LLKQGLNNAV 3060
ALDFDYREQM IYWTDVTTQG SMIRRMHLNG SNVQVLHRTG LSNPDGLAVD WVGGNLYWCD 3120
KGRDTIEVSK LNGAYRTVLV SSGLREPRAL VVDVQNGYLY WTDWGDHSLI GRIGMDGSSR 3180
SVIVDTKITW PNGLTLDYVT ERIYWADARE DYIEFASLDG SNRHVVLSQD IPHIFALTLF 3240
EDYVYWTDWE TKSINRAHKT TGTNKTLLIS TLHRPMDLHV FHALRQPDVP NHPCKVNNGG 3300
CSNLCLLSPG GGHKCACPTN FYLGSDGRTC VSNCTASQFV CKNDKCIPFW WKCDTEDDCG 3360
DHSDEPPDCP EFKCRPGQFQ CSTGICTNPA FICDGDNDCQ DNSDEANCDI HVCLPSQFKC 3420
TNTNRCIPGI FRCNGQDNCG DGEDERDCPE VTCAPNQFQC SITKRCIPRV WVCDRDNDCV 3480
DGSDEPANCT QMTCGVDEFR CKDSGRCIPA RWKCDGEDDC GDGSDEPKEE CDERTCEPYQ 3540
FRCKNNRCVP GRWQCDYDND CGDNSDEESC TPRPCSESEF SCANGRCIAG RWKCDGDHDC 3600
ADGSDEKDCT PRCDMDQFQC KSGHCIPLRW RCDADADCMD GSDEEACGTG VRTCPLDEFQ 3660
CNNTLCKPLA WKCDGEDDCG DNSDENPEEC ARFVCPPNRP FRCKNDRVCL WIGRQCDGTD 3720
NCGDGTDEED CEPPTAHTTH CKDKKEFLCR NQRCLSSSLR CNMFDDCGDG SDEEDCSIDP 3780
KLTSCATNAS ICGDEARCVR TEKAAYCACR SGFHTVPGQP GCQDINECLR FGTCSQLCNN 3840
TKGGHLCSCA RNFMKTHNTC KAEGSEYQVL YIADDNEIRS LFPGHPHSAY EQAFQGDESV 3900
RIDAMDVHVK AGRVYWTNWH TGTISYRSLP PAAPPTTSNR HRRQIDRGVT HLNISGLKMP 3960
RGIAIDWVAG NVYWTDSGRD VIEVAQMKGE NRKTLISGMI DEPHAIVVDP LRGTMYWSDW 4020
GNHPKIETAA MDGTLRETLV QDNIQWPTGL AVDYHNERLY WADAKLSVIG SIRLNGTDPI 4080
VAADSKRGLS HPFSIDVFED YIYGVTYINN RVFKIHKFGH SPLVNLTGGL SHASDVVLYH 4140
QHKQPEVTNP CDRKKCEWLC LLSPSGPVCT CPNGKRLDNG TCVPVPSPTP PPDAPRPGTC 4200
NLQCFNGGSC FLNARRQPKC RCQPRYTGDK CELDQCWEHC RNGGTCAASP SGMPTCRCPT 4260
GFTGPKCTQQ VCAGYCANNS TCTVNQGNQP QCRCLPGFLG DRCQYRQCSG YCENFGTCQM 4320
AADGSRQCRC TAYFEGSRCE VNKCSRCLEG ACVVNKQSGD VTCNCTDGRV APSCLTCVGH 4380
CSNGGSCTMN SKMMPECQCP PHMTGPRCEE HVFSQQQPGH IASILIPLLL LLLLVLVAGV 4440
VFWYKRRVQG AKGFQHQRMT NGAMNVEIGN PTYKMYEGGE PDDVGGLLDA DFALDPDKPT 4500
NFTNPVYATL YMGGHGSRHS LASTDEKREL LGRGPEDEIG DPLA 4544 
Gene Ontology
 GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
 GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0034185; F:apolipoprotein binding; IDA:UniProtKB.
 GO:0005509; F:calcium ion binding; ISS:UniProtKB.
 GO:0070325; F:lipoprotein particle receptor binding; IC:BHF-UCL.
 GO:0042954; F:lipoprotein transporter activity; NAS:UniProtKB.
 GO:0032403; F:protein complex binding; IDA:BHF-UCL.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0035909; P:aorta morphogenesis; ISS:BHF-UCL.
 GO:0043277; P:apoptotic cell clearance; ISS:BHF-UCL.
 GO:0097242; P:beta-amyloid clearance; TAS:BHF-UCL.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:2000587; P:negative regulation of platelet-derived growth factor receptor-beta signaling pathway; ISS:BHF-UCL.
 GO:0014912; P:negative regulation of smooth muscle cell migration; ISS:BHF-UCL.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; ISS:BHF-UCL.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0010875; P:positive regulation of cholesterol efflux; ISS:BHF-UCL.
 GO:0006898; P:receptor-mediated endocytosis; IEA:Compara.
 GO:0032956; P:regulation of actin cytoskeleton organization; ISS:BHF-UCL.
 GO:0032429; P:regulation of phospholipase A2 activity; ISS:BHF-UCL.
 GO:0001523; P:retinoid metabolic process; TAS:Reactome. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR026823; cEGF.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR023415; LDLR_class-A_CS.
 IPR000033; LDLR_classB_rpt.
 IPR002172; LDrepeatLR_classA_rpt. 
Pfam
 PF12662; cEGF
 PF07645; EGF_CA
 PF00057; Ldl_recept_a
 PF00058; Ldl_recept_b 
SMART
 SM00181; EGF
 SM00179; EGF_CA
 SM00192; LDLa
 SM00135; LY 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS51120; LDLRB 
PRINTS