UniProt Accession

 ITM2B_MOUSE; O89051; Q545S7 

Genbank Protein ID

 U76253; AB030203; AK002599; AK003587; AK005125; AK076139; AK077482; AK150378; AK151714; AK151889; AK152068; AK152516; AK152650; AK152731; AK152983; AK153103; AK159340; AK159426; AK159619; AK159628; AK159792; AK159962; AK160725; BC004731; BC010320; BC021786 

Genbank Nucleotide ID

 AAC63851.1; BAA92766.1; BAB22220.1; BAB22877.1; BAB23828.1; BAC36212.1; BAC36822.1; BAE29510.1; BAE30633.1; BAE30773.1; BAE30922.1; BAE31278.1; BAE31387.1; BAE31452.1; BAE31632.1; BAE31723.1; BAE35002.1; BAE35073.1; BAE35235.1; BAE35242.1; BAE35374.1; BAE35517.1; BAE35970.1; AAH04731.1; AAH10320.1; AAH21786.1 

Protein Name

 Integral membrane protein 2B 

Protein Synonyms/Alias

 Immature BRI2; imBRI2; Protein E25B; Transmembrane protein BRI; Bri; BRI2, membrane form; Mature BRI2; mBRI2; BRI2 intracellular domain; BRI2 ICD; BRI2C, soluble form; Bri23 peptide; Bri2-23; ABri23; C-terminal peptide; P23 peptide 

Gene Name

 Itm2b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
3	*****MVKVTFNSAL	ubiquitination	[1]
13	FNSALAQKEAKKDEP	ubiquitination	[1]
16	ALAQKEAKKDEPKSS	ubiquitination	[1]
17	LAQKEAKKDEPKSSE	ubiquitination	[1]
39	DAVAVDCKDPGDVVP	ubiquitination	[1, 2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144] 

Functional Description

 Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity). 

Sequence Annotation

 DOMAIN 137 231 BRICHOS.
 REGION 102 134 Necessary for interaction with APP and
 CARBOHYD 170 170 N-linked (GlcNAc...) (Potential).
 DISULFID 89 89 Interchain (By similarity).
 DISULFID 164 223 By similarity.
 DISULFID 248 265 By similarity.  

Keyword

 Cell membrane; Complete proteome; Disulfide bond; Endosome; Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Secreted; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 266 AA 

Protein Sequence

Gene Ontology

 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; ISS:UniProtKB.
 GO:0030660; C:Golgi-associated vesicle membrane; ISS:UniProtKB.
 GO:0031301; C:integral to organelle membrane; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IDA:MGI.
 GO:0001540; F:beta-amyloid binding; IEA:Compara.
 GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IDA:MGI.
 GO:0042985; P:negative regulation of amyloid precursor protein biosynthetic process; ISS:UniProtKB. 

Interpro

 IPR007084; BRICHOS_dom. 

Pfam

 PF04089; BRICHOS 

SMART

 SM01039; BRICHOS 

PROSITE

 PS50869; BRICHOS 

PRINTS