UniProt Accession

 GLMN_HUMAN; Q92990; Q5VVC3; Q9BVE8 

Genbank Protein ID

 U73704; AJ347709; AJ302735; AJ302727; AJ302728; AJ302729; AJ302730; AJ302731; AJ302732; AJ302733; AJ302734; AL451010; CH471097; BC001257 

Genbank Nucleotide ID

 AAC50908.1; CAC69882.1; CAC82938.1; CAC88124.1; CAC88124.1; CAC88124.1; CAC88124.1; CAC88124.1; CAC88124.1; CAC88124.1; CAC88124.1; CAH70761.1; EAW73098.1; AAH01257.1 

Protein Name

 Glomulin 

Protein Synonyms/Alias

 FK506-binding protein-associated protein; FAP; FKBP-associated protein 

Gene Name

 GLMN 

Gene Synonyms/Alias

 FAP48; FAP68; VMGLOM 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	EELQSIIKRCQILEE	ubiquitination	[1, 2]
55	IIQNEKNKVIIKNMG	ubiquitination	[2]
59	EKNKVIIKNMGWNLV	ubiquitination	[2]
185	KALIEFTKPFVEEVI	ubiquitination	[3]
195	VEEVIDNKENSLENE	ubiquitination	[3]
214	ELLKFCFKSLKCPLL	ubiquitination	[2]
217	KFCFKSLKCPLLTAQ	ubiquitination	[2]
433	NQIDMSLKRTRNNKW	ubiquitination	[3]
525	AHYEAEIKNSQEAQK	ubiquitination	[3]
584	ELIEIKTKSTSEENI	ubiquitination	[3]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Disease mutation; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 594 AA 

Protein Sequence

Gene Ontology

 GO:0031462; C:Cul2-RING ubiquitin ligase complex; IPI:MGI.
 GO:0031463; C:Cul3-RING ubiquitin ligase complex; IPI:MGI.
 GO:0031464; C:Cul4A-RING ubiquitin ligase complex; IPI:MGI.
 GO:0031625; F:ubiquitin protein ligase binding; IDA:MGI.
 GO:0055105; F:ubiquitin-protein ligase inhibitor activity; IGI:MGI.
 GO:0042692; P:muscle cell differentiation; IMP:UniProtKB.
 GO:0042130; P:negative regulation of T cell proliferation; IDA:UniProtKB.
 GO:0050715; P:positive regulation of cytokine secretion; IMP:UniProtKB.
 GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IMP:UniProtKB.
 GO:0042327; P:positive regulation of phosphorylation; IDA:UniProtKB.
 GO:0040029; P:regulation of gene expression, epigenetic; IMP:UniProtKB.
 GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI.
 GO:0001570; P:vasculogenesis; IMP:UniProtKB. 

Interpro

 IPR019516; Glomulin.
 IPR013877; YAP-bd/Alf4/glomulin. 

Pfam

 PF08568; Kinetochor_Ybp2 

SMART

  

PROSITE

  

PRINTS