| Tag | Content |
|---|
| CPLM ID | CPLM-004226 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sensor protein ZraS |
Protein Synonyms/Alias | |
Gene Name | zraS |
Gene Synonyms/Alias | hydH; b4003; JW3967 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 268 | SSIKGLAKYFAERAP | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium. |
Sequence Annotation | DOMAIN 251 458 Histidine kinase.
MOD_RES 254 254 Phosphohistidine; by autocatalysis (By |
Keyword | ATP-binding; Cell inner membrane; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Two-component regulatory system; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 465 AA |
Protein Sequence | MRFMQRSKDS LAKWLSAILP VVIVGLVGLF AVTVIRDYGR ASEADRQALL EKGNVLIRAL 60
ESGSRVGMGM RMHHVQQQAL LEEMAGQPGV LWFAVTDAQG IIILHSDPDK VGRALYSPDE 120
MQKLKPEENS RWRLLGKTET TPALEVYRLF QPMSAPWRHG MHNMPRCNGK AVPQVDAQQA 180
IFIAVDASDL VATQSGEKRN TLIILFALAT VLLASVLSFF WYRRYLRSRQ LLQDEMKRKE 240
KLVALGHLAA GVAHEIRNPL SSIKGLAKYF AERAPAGGEA HQLAQVMAKE ADRLNRVVSE 300
LLELVKPTHL ALQAVDLNTL INHSLQLVSQ DANSREIQLR FTANDTLPEI QADPDRLTQV 360
LLNLYLNAIQ AIGQHGVISV TASESGAGVK ISVTDSGKGI AADQLDAIFT PYFTTKAEGT 420
GLGLAVVHNI VEQHGGTIQV ASQEGKGSTF TLWLPVNITR KDPQG 465 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IDA:EcoCyc. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0000155; F:phosphorelay sensor kinase activity; IMP:EcoCyc. GO:0071284; P:cellular response to lead ion; IEP:EcoCyc. GO:0071294; P:cellular response to zinc ion; IEP:EcoCyc. GO:0046777; P:protein autophosphorylation; IDA:EcoCyc. |
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