Tag | Content |
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CPLM ID | CPLM-021064 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dimethylaniline monooxygenase [N-oxide-forming] 3 |
Protein Synonyms/Alias | Dimethylaniline oxidase 3; Hepatic flavin-containing monooxygenase 3; FMO 3; Trimethylamine monooxygenase |
Gene Name | Fmo3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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265 | KQMNARFKHENYGLM | acetylation | [1] | 478 | FRLVGPGKWSGARNA | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Acts on TMA to produce TMA-N-oxide. Has activities of methimazole S-oxidation and NADPH oxidation associated with the N- or S- oxidation of trimethylamine and thioacetamide. |
Sequence Annotation | NP_BIND 9 14 FAD (Potential). NP_BIND 191 196 NADP (Potential). MOD_RES 401 401 Phosphoserine (By similarity). |
Keyword | Complete proteome; Endoplasmic reticulum; FAD; Flavoprotein; Membrane; Microsome; Monooxygenase; NADP; Oxidoreductase; Phosphoprotein; Reference proteome; Transmembrane. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 531 AA |
Protein Sequence | MKRKVAVIGA GVSGLAAIRS CLEEGLEPTC FERSDDVGGL WKFSDHTEEG RASIYQSVFT 60 NSSKEMMCFP DFPYPDDFPN FMHNSKLQEY ITSFATEKNL LKYIQFETLV TRINKCPDFS 120 TTGKWEVTTE KNSKKETAVF DAVMICSGHH VYPHLPKDSF PGLNRFKGKC FHSRDYKEPG 180 TWKGKRVLVI GLGNSGCDIA AELSHVAQQV IISSRSGSWV MSRVWNDGYP WDMVVITRFQ 240 TFLKNNLPTA ISDWWYMKQM NARFKHENYG LMPLNGTLRK EPVFNDELPA RILCGTVSIK 300 PNVKEFTETS AVFEDGTVFE GIDCVIFATG YGYAYPFLDD SIIKSRNNEV TLYKGIFPPQ 360 LEKPTMAVIG LVQSLGAAIP TTDLQARWAA QVIRGTCILP SVNDMMDDID EKMGKKLKWF 420 GNSTTIQTDY IVYMDELASF IGAKPNILWL FLKDPRLAIE VFFGPCSPYQ FRLVGPGKWS 480 GARNAILTQW DRSLKPMKTR VVGGIQKPCL YSHFLRLLAV PVLIALFLVL I 531 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD. GO:0031227; C:intrinsic to endoplasmic reticulum membrane; IEA:InterPro. GO:0016597; F:amino acid binding; IPI:RGD. GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IDA:RGD. GO:0050661; F:NADP binding; IPI:RGD. GO:0034899; F:trimethylamine monooxygenase activity; IEA:EC. GO:0017144; P:drug metabolic process; IDA:RGD. |
Interpro | |
Pfam | |
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PRINTS | |