CPLM-019829

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-019829

UniProt Accession

GDF15_HUMAN; Q99988; O14629; P78360; Q9BWA0; Q9NRT0

Genbank Protein ID

U88323; AB000584; AF019770; AF003934; AK291530; BT019465; AC008397; CH471106; BC000529; BC008962; AF008303; AF173860

Genbank Nucleotide ID

AAB88913.1; BAA19151.1; AAB88673.1; AAC24456.1; BAF84219.1; AAV38272.1; EAW84694.1; AAH00529.1; AAH08962.1; AAC39537.1; AAF89834.1

Protein Name

Growth/differentiation factor 15

Protein Synonyms/Alias

GDF-15; Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor

Gene Name

GDF15

Gene Synonyms/Alias

MIC1; PDF; PLAB; PTGFB

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
265	KTSLHRLKPDTVPAP	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Sequence Annotation

CARBOHYD 70 70 N-linked (GlcNAc...) (Potential).
DISULFID 211 274 By similarity.
DISULFID 240 305 By similarity.
DISULFID 244 307 By similarity.
DISULFID 273 273 Interchain (By similarity).

Keyword

Cleavage on pair of basic residues; Complete proteome; Cytokine; Disulfide bond; Glycoprotein; Growth factor; Polymorphism; Reference proteome; Secreted; Signal.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

308 AA

Protein Sequence

MPGQELRTVN GSQMLLVLLV LSWLPHGGAL SLAEASRASF PGPSELHSED SRFRELRKRY 60
EDLLTRLRAN QSWEDSNTDL VPAPAVRILT PEVRLGSGGH LHLRISRAAL PEGLPEASRL 120
HRALFRLSPT ASRSWDVTRP LRRQLSLARP QAPALHLRLS PPPSQSDQLL AESSSARPQL 180
ELHLRPQAAR GRRRARARNG DHCPLGPGRC CRLHTVRASL EDLGWADWVL SPREVQVTMC 240
IGACPSQFRA ANMHAQIKTS LHRLKPDTVP APCCVPASYN PMVLIQKTDT GVSLQTYDDL 300
LAKDCHCI 308

Gene Ontology

GO:0005576; C:extracellular region; TAS:ProtInc.
GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO:0005125; F:cytokine activity; TAS:ProtInc.
GO:0007267; P:cell-cell signaling; TAS:ProtInc.
GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:ProtInc.

Interpro

IPR001839; TGF-b_C.
IPR015615; TGF-beta-rel.

Pfam

PF00019; TGF_beta

SMART

SM00204; TGFB

PROSITE

PS00250; TGF_BETA_1
PS51362; TGF_BETA_2

PRINTS