CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032441
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 
Protein Synonyms/Alias
  
Gene Name
 PLCH2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
468TRQKKTMKLSRALSDubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Transducer. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1058 AA 
Protein Sequence
MAGISDEDSL ARRQRTRDQW LKQTFDEADK NGDGSLSIGE VLQLLHKLNV NLPRQRVKQM 60
FREADTDDHQ GTLGFEEFCA FYKMMSTRRD LYLLMLTYSN HKDHLDAASL QRFLQVEQKM 120
AGVTLESCQD IIEQFEPCPE NKSKGLLGID GFTNYTRSPA GDIFNPEHHH VHQDMTQPLS 180
HYFITSSHNT YLVGDQLMSQ SRVDMYAWVL QAGCRCVEVD CWDGPDGEPI VHHGYTLTSK 240
ILFKDVIETI NKYAFIKNEY PVILSIENHC SVIQQKKMAQ YLTDILGDKL DLSSVSSEDA 300
TTLPSPQMLK GKILVKGKKL PANISEDAEE GEVSDEDSAD EIDDDCKLLN GDASTNRKRV 360
ENTAKRKLDS LIKESKIRDC EDPNNFSVST LSPSGKLGRK SKAEEDVESG EDAGASRRNG 420
RLVVGSFSRR KKKGSKLKKA ASVEEGDEGQ DSPGGQSRGA TRQKKTMKLS RALSDLVKYT 480
KSVATHDIEM EAASSWQVSS FSETKAHQIL QQKPAQYLRF NQQQLSRIYP SSYRVDSSNY 540
NPQPFWNAGC QMVALNYQSE GRMLQLNRAK FSANGGCGYV LKPGCMCQGV FNPNSEDPLP 600
GQLKKQLVLR IISGQQLPKP RDSMLGDRGE IIDPFVEVEI IGLPVDCSRE QTRVVDDNGF 660
NPTWEETLVF MVHMPEIALV RFLVWDHDPI GRDFIGQRTL AFSSMMPGYR HVYLEGMEEA 720
SIFVHVAVSD ISGKVKQALG LKGLFLRGPK PGSLDSHAAG RPPARPSVSQ RILRRTASAP 780
TKSQKPGRRG FPELVLGTRD TGSKGVADDV VPPGPGPAPE APAQEGPGSG SPRGKAPAAV 840
AEKSPVRVRP PRVLDGPGPA GMAATCMKCV VGSCAGVNTG GLQRERPPSP GPASRQAAIR 900
QQPRARADSL GAPCCGLDPH AIPGRSREAP KGPGAWRQGP GGSGSMSSDS SSPDSPGIPE 960
RSPRWPEGAC RQPGALQGEM SALFAQKLEE IRSKSPMFSA GKPLLPCVVL PHAPGMAGPG 1020
SPAAASAWTV SPRVLVLVAL YPWHCLRGTL LPWLACGP 1058 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0006629; P:lipid metabolic process; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR001192; Pinositol_PLipase_C.
 IPR017946; PLC-like_Pdiesterase_TIM-brl.
 IPR015359; PLipase_C_EF-hand-like.
 IPR000909; PLipase_C_PInositol-sp_X_dom.
 IPR001711; PLipase_C_Pinositol-sp_Y. 
Pfam
 PF00168; C2
 PF13499; EF_hand_5
 PF09279; efhand_like
 PF00388; PI-PLC-X
 PF00387; PI-PLC-Y 
SMART
 SM00239; C2
 SM00054; EFh
 SM00148; PLCXc
 SM00149; PLCYc 
PROSITE
 PS50004; C2
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50007; PIPLC_X_DOMAIN
 PS50008; PIPLC_Y_DOMAIN 
PRINTS
 PR00390; PHPHLIPASEC.