| Tag | Content |
|---|
| CPLM ID | CPLM-004490 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Chitobiosyldiphosphodolichol beta-mannosyltransferase |
Protein Synonyms/Alias | Asparagine-linked glycosylation protein 1; Beta-1,4-mannosyltransferase; GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase; GDP-mannose-dolichol diphosphochitobiose mannosyltransferase |
Gene Name | ALG1 |
Gene Synonyms/Alias | YBR110W; YBR0906 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 424 | DLYQKLKKNVTQEAE | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER. |
Sequence Annotation | REGION 435 449 Required for oligomerization.
MOTIF 21 32 Dolichol recognition (Potential).
CARBOHYD 88 88 N-linked (GlcNAc...) (Potential).
CARBOHYD 199 199 N-linked (GlcNAc...) (Potential).
CARBOHYD 425 425 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 449 AA |
Protein Sequence | MFLEIPRWLL ALIILYLSIP LVVYYVIPYL FYGNKSTKKR IIIFVLGDVG HSPRICYHAI 60
SFSKLGWQVE LCGYVEDTLP KIISSDPNIT VHHMSNLKRK GGGTSVIFMV KKVLFQVLSI 120
FKLLWELRGS DYILVQNPPS IPILPIAVLY KLTGCKLIID WHNLAYSILQ LKFKGNFYHP 180
LVLISYMVEM IFSKFADYNL TVTEAMRKYL IQSFHLNPKR CAVLYDRPAS QFQPLAGDIS 240
RQKALTTKAF IKNYIRDDFD TEKGDKIIVT STSFTPDEDI GILLGALKIY ENSYVKFDSS 300
LPKILCFITG KGPLKEKYMK QVEEYDWKRC QIEFVWLSAE DYPKLLQLCD YGVSLHTSSS 360
GLDLPMKILD MFGSGLPVIA MNYPVLDELV QHNVNGLKFV DRRELHESLI FAMKDADLYQ 420
KLKKNVTQEA ENRWQSNWER TMRDLKLIH 449 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IPI:SGD. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; ISS:SGD. GO:0019187; F:beta-1,4-mannosyltransferase activity; IDA:SGD. GO:0004578; F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity; IEA:EC. GO:0006490; P:oligosaccharide-lipid intermediate biosynthetic process; IMP:SGD. GO:0006487; P:protein N-linked glycosylation; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |