| Tag | Content |
|---|
| CPLM ID | CPLM-008680 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RNA exonuclease 1 |
Protein Synonyms/Alias | RNase H(70) |
Gene Name | RNH70 |
Gene Synonyms/Alias | REX1; YGR276C; G9381 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 50 | NKKKKKAKPMTCTLL | ubiquitination | [1] | | 58 | PMTCTLLKSVVEKGI | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | 3' exoribonuclease required for 5S rRNA maturation and for the proper maturation of the 5' cistron of the tRNA-Arg3 dicistronic gene. Involved with REX2 in the maturation of the 5.8S rRNA, and with REX2 and REX3, in the 3' processing of the U5L snRNA. |
Sequence Annotation | DOMAIN 225 373 Exonuclease.
MOD_RES 24 24 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; Direct protein sequencing; Exonuclease; Hydrolase; Nuclease; Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing; tRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 553 AA |
Protein Sequence | MQVEGPDTNF VSDLALGSKK RRLSKTSVQE DDHTNVVSEV NKNKKKKKAK PMTCTLLKSV 60
VEKGIGIKDV RDMTQYLLQA ENNSPKWIDI CNRSSLQKMI VLFIPGLQPD DFENGKNTFN 120
EISDDNFKYI PGEIASTFHT FPVMAPGSKM TLFSPYNSFI NVGLSKMEKI NKLKELQKKK 180
KITINDLVLS EQQLVANDYP LDSGDTNFDT DWVQTVDFTH GGSHIFALDC EMCLSEQGLV 240
LTRISLVNFD NEVIYEELVK PDVPIVDYLT RYSGITEEKL TVGAKKTLRE VQKDLLKIIS 300
RSDILIGHSL QNDLKVMKLK HPLVVDTAII YHHKAGDPFK PSLKYLSETF LNKSIQNGEH 360
DSVEDARACL ELTKLKILNG LAFGIGINTE NLFTKLHRFE VKTVLLNDMI IKNHTEDDSK 420
GQLIRCVEDD ETWTHIHENL NKDVKLIVGR IKNLERSRNY NKKPRKETPS FDASMVLHDI 480
GQHLTQLYEN ATPGTMILIM SGTGDTRPWN NLSTELEFIQ DKKERLDKRR EREPEIVEAI 540
KLARGGVASF TVK 553 |
Gene Ontology | GO:0005634; C:nucleus; IDA:SGD. GO:0000175; F:3'-5'-exoribonuclease activity; IMP:SGD. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IGI:SGD. GO:0002107; P:generation of mature 3'-end of 5S rRNA generated by RNA polymerase III; IMP:SGD. GO:0034415; P:tRNA 3'-trailer cleavage, exonucleolytic; IMP:SGD. GO:0034476; P:U5 snRNA 3'-end processing; IGI:SGD. |
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PRINTS | |