CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038652
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Glycogen synthase kinase-3 beta 
Protein Synonyms/Alias
  
Gene Name
 Gsk3b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
205LCDFGSAKQLVRGEPubiquitination[1]
292NPNYTEFKFPQIKAHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 433 AA 
Protein Sequence
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 60
VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 120
EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR 180
DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 240
WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300
WTKDSPGAGH FTPGVRVFRP RTPPEAIALC SRLLEYTPTA RLTPLEACAH SFFDELRDPN 360
VKLPNGRDTP ALFNFTTQEL SSNPPLATIL IPPHARIQAA ASPPANATAA SDTNAGDRGQ 420
TNNAASASAS NST 433 
Gene Ontology
 GO:0030877; C:beta-catenin destruction complex; IDA:MGI.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0043198; C:dendritic shaft; IDA:MGI.
 GO:0030426; C:growth cone; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0030529; C:ribonucleoprotein complex; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:MGI.
 GO:0050321; F:tau-protein kinase activity; IDA:MGI.
 GO:0007409; P:axonogenesis; IGI:MGI.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:MGI.
 GO:0016477; P:cell migration; IGI:MGI.
 GO:0008283; P:cell proliferation; TAS:MGI.
 GO:0006983; P:ER overload response; IDA:MGI.
 GO:0045444; P:fat cell differentiation; IDA:MGI.
 GO:0035556; P:intracellular signal transduction; ISO:MGI.
 GO:0007520; P:myoblast fusion; IDA:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IDA:MGI.
 GO:0009887; P:organ morphogenesis; IMP:MGI.
 GO:0018105; P:peptidyl-serine phosphorylation; IDA:MGI.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:MGI.
 GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IDA:MGI.
 GO:0032092; P:positive regulation of protein binding; IDA:MGI.
 GO:2000738; P:positive regulation of stem cell differentiation; IMP:MGI.
 GO:0006611; P:protein export from nucleus; IDA:MGI.
 GO:0035372; P:protein localization to microtubule; IGI:MGI.
 GO:0000320; P:re-entry into mitotic cell cycle; IDA:MGI. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS