UniProt Accession

 BBS4_MOUSE; Q8C1Z7; Q3UYF0; Q562E1; Q5EBJ7; Q8CA57 

Genbank Protein ID

 AK039560; AK089970; AK134734; BC055797; BC089507; BC092531 

Genbank Nucleotide ID

 BAC30384.1; BAC41021.1; BAE22262.1; AAH55797.1; AAH89507.1; AAH92531.1 

Protein Name

 Bardet-Biedl syndrome 4 protein homolog 

Protein Synonyms/Alias

  

Gene Name

 Bbs4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
20	PASVESQKPRSKKAP	acetylation	[1, 2]
20	PASVESQKPRSKKAP	ubiquitination	[3]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane (By similarity). 

Sequence Annotation

 REPEAT 67 100 TPR 1.
 REPEAT 102 134 TPR 2.
 REPEAT 135 167 TPR 3.
 REPEAT 168 201 TPR 4.
 REPEAT 203 235 TPR 5.
 REPEAT 237 269 TPR 6.
 REPEAT 270 303 TPR 7.
 REPEAT 304 337 TPR 8.
 REPEAT 339 371 TPR 9.
 REPEAT 373 408 TPR 10.
 REGION 1 66 Required for localization to centrosomes
 REGION 101 337 Interaction with PCM1 (By similarity).
 REGION 338 520 Required for localization to centrosomes  

Keyword

 Cell membrane; Cell projection; Cilium; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 520 AA 

Protein Sequence

Gene Ontology

 GO:0034464; C:BBSome; IDA:MGI.
 GO:0034451; C:centriolar satellite; IEA:Compara.
 GO:0005814; C:centriole; IEA:Compara.
 GO:0060170; C:cilium membrane; IEA:UniProtKB-SubCell.
 GO:0005932; C:microtubule basal body; IEA:Compara.
 GO:0031514; C:motile cilium; IMP:BHF-UCL.
 GO:0031513; C:nonmotile primary cilium; IEA:Compara.
 GO:0000242; C:pericentriolar material; ISS:UniProtKB.
 GO:0003777; F:microtubule motor activity; ISS:UniProtKB.
 GO:0030534; P:adult behavior; IMP:MGI.
 GO:0048854; P:brain morphogenesis; IMP:MGI.
 GO:0051297; P:centrosome organization; ISS:UniProtKB.
 GO:0021987; P:cerebral cortex development; IMP:MGI.
 GO:0016358; P:dendrite development; IMP:MGI.
 GO:0045444; P:fat cell differentiation; IEP:BHF-UCL.
 GO:0021766; P:hippocampus development; IMP:MGI.
 GO:0051457; P:maintenance of protein location in nucleus; IEA:Compara.
 GO:0034454; P:microtubule anchoring at centrosome; IEA:Compara.
 GO:0038108; P:negative regulation of appetite by leptin-mediated signaling pathway; IMP:BHF-UCL.
 GO:0010629; P:negative regulation of gene expression; IMP:MGI.
 GO:0003085; P:negative regulation of systemic arterial blood pressure; IMP:MGI.
 GO:0001843; P:neural tube closure; IMP:MGI.
 GO:0035058; P:nonmotile primary cilium assembly; IMP:MGI.
 GO:0045494; P:photoreceptor cell maintenance; IMP:MGI.
 GO:0045724; P:positive regulation of cilium assembly; IMP:MGI.
 GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
 GO:0033365; P:protein localization to organelle; IDA:BHF-UCL.
 GO:0060296; P:regulation of cilium beat frequency involved in ciliary motility; IMP:BHF-UCL.
 GO:0032465; P:regulation of cytokinesis; IEA:Compara.
 GO:0019216; P:regulation of lipid metabolic process; IMP:MGI.
 GO:0001895; P:retina homeostasis; IMP:MGI.
 GO:0046548; P:retinal rod cell development; IMP:MGI.
 GO:0007608; P:sensory perception of smell; IMP:MGI.
 GO:0007286; P:spermatid development; IMP:MGI.
 GO:0021756; P:striatum development; IMP:MGI. 

Interpro

 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 

Pfam

 PF07719; TPR_2 

SMART

 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS