CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014700
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldose 1-epimerase 
Protein Synonyms/Alias
 Galactose mutarotase 
Gene Name
 Galm 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
21SGGGAVEKFQLRSDQacetylation[1]
93GRFTVDGKEYHLPINacetylation[1]
226GTAFDLRKPVELGKHacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). 
Sequence Annotation
 REGION 81 82 Substrate binding (By similarity).
 ACT_SITE 176 176 Proton donor (By similarity).
 ACT_SITE 307 307 Proton acceptor (By similarity).
 BINDING 243 243 Substrate (By similarity).  
Keyword
 Carbohydrate metabolism; Complete proteome; Cytoplasm; Direct protein sequencing; Isomerase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 342 AA 
Protein Sequence
MVSVTRTVFG ELPSGGGAVE KFQLRSDQLN VDIISWGCTI TALQVKDRQG KASDVVLGFA 60
ELEGYLQKQP YFGAVVGRVA NRIAKGRFTV DGKEYHLPIN REPNSLHGGF RGFDKVLWTP 120
QVLSNGVQFS RVSPDGEEGY PGELKVWVTY TLDGGELVVN YRAQASQTTP VNLTNHSYFN 180
LAGQGSPDIY DHEVTIAADA YLPVDETLIP TGVIAPVEGT AFDLRKPVEL GKHLQSYHIH 240
GFDHNFCLKE SKEKKFCARV HHAASGRILE VYTTQPGVQF YTGNFLDGTL KGKSGEVYPK 300
HSGFCLETQN WPDAVNQPQF PPILLRPGEE YNHTTWFKFS VA 342 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004034; F:aldose 1-epimerase activity; IEA:EC.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR018052; Ald1_epimerase_CS.
 IPR015443; Aldose_1-epimerase.
 IPR008183; Aldose_1/G6P_1-epimerase.
 IPR011013; Gal_mutarotase_SF_dom.
 IPR014718; Glyco_hydro-type_carb-bd_sub. 
Pfam
 PF01263; Aldose_epim 
SMART
  
PROSITE
 PS00545; ALDOSE_1_EPIMERASE 
PRINTS