| Tag | Content |
|---|
| CPLM ID | CPLM-027036 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Multidrug resistance protein |
Protein Synonyms/Alias | |
Gene Name | PfMDR1 |
Gene Synonyms/Alias | PFE1150w |
Created Date | July 27, 2013 |
Organism | Plasmodium falciparum (isolate 3D7) |
NCBI Taxa ID | 36329 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1096 | NAKLSFEKYYPLMIR | acetylation | [1] |
|
Reference | [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development. Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L. Mol Microbiol. 2013 Aug;89(4):660-75. [ PMID: 23796209] |
Functional Description | |
Sequence Annotation | |
Keyword | ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1419 AA |
Protein Sequence | MGKEQKEKKD GNLSIKEEVE KELNKKSTAE LFRKIKNEKI SFFLPFKCLP AQHRKLLFIS 60
FVCAVLSGGT LPFFISVFGV ILKNMNLGDD INPIILSLVS IGLVQFILSM ISSYCMDVIT 120
SKILKTLKLE YLRSVFYQDG QFHDNNPGSK LRSDLDFYLE QVSSGIGTKF ITIFTYASSF 180
LGLYIWSLIK NARLTLCITC VFPLIYVCGV ICNKKVKLNK KTSLLYNNNT MSIIEEALMG 240
IRTVASYCGE KTILNKFNLS ETFYSKYILK ANFVEALHIG LINGLILVSY AFGFWYGTRI 300
IINSATNQYP NNDFNGASVI SILLGVLISM FMLTIILPNI TEYMKALEAT NSLYEIINRK 360
PLVENNDDGE TLPNIKKIEF KNVRFHYDTR KDVEIYKDLS FTLKEGKTYA FVGESGCGKS 420
TILKLIERLY DPTEGDIIVN DSHNLKDINL KWWRSKIGVV SQDPLLFSNS IKNNIKYSLY 480
SLKDLEAMEN YYEENTNDTY ENKNFSLISN SMTSNELLEM KKEYQTIKDS DVVDVSKKVL 540
IHDFVSSLPD KYDTLVGSNA SKLSGGQKQR ISIARAIMRN PKILILDEAT SSLDNKSEYL 600
VQKTINNLKG NENRITIIIA HRLSTIRYAN TIFVLSNRER SDNNNNNNND DNNNNNNNNN 660
NKINNEGSYI IEQGTHDSLM KNKNGIYHLM INNQKISSNK SSNNGNDNGS DNKSSAYKDS 720
DTGNDADNMN SLSIHENENI SNNRNCKNTA ENEKEEKVPF FKRMFRRKKK APNNLRIIYK 780
EIFSYKKDVT IIFFSILVAG GLYPVFALLY ARYVSTLFDF ANLEYNSNKY SIYILLIAIA 840
MFISETLKNY YNNKIGEKVE KTMKRRLFEN ILYQEMSFFD QDKNTPGVLS AHINRDVHLL 900
KTGLVNNIVI FSHFIMLFLV SMVMSFYFCP IVAAVLTFIY FINMRVFAVR ARLTKSKEIE 960
KKENMSSGVF AFSSDDEMFK DPSFLIQEAF YNMHTVINYG LEDYFCNLIE KAIDYKNKGQ 1020
KRRIIVNAAL WGFSQSAQLF INSFAYWFGS FLIKRGTILV DDFMKSLFTF IFTGSYAGKL 1080
MSLKGDSENA KLSFEKYYPL MIRKSNIDVR DDGGIRINKN LIKGKVDIKD VNFRYISRPN 1140
VPIYKNLSFT CDSKKTTAIV GETGSGKSTF MNLLLRFYDL KNDHIILKND MTNFQDYQNN 1200
NNNSLVLKNV NEFSNQSGSA EDYTVFNNNG EILLDDINIC DYNLRDLRNL FSIVSQEPML 1260
FNMSIYENIK FGREDATLED VKRVSKFAAI DEFIESLPNK YDTNVGPYGK SLSGGQKQRI 1320
AIARALLREP KILLLDEATS SLDSNSEKLI EKTIVDIKDK ADKTIITIAH RIASIKRSDK 1380
IVVFNNPDRN GTFVQSHGTH DELLSAQDGI YKKYVKLAK 1419 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. GO:0006200; P:ATP catabolic process; IEA:GOC. GO:0042493; P:response to drug; IDA:GeneDB_Pfalciparum. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |