CPLM-017360

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-017360

UniProt Accession

ABD12_HUMAN; Q8N2K0; A6NED4; A6NJ90; A8K450; B4DE71; Q5T710; Q5T711; Q96CR1; Q9BX05; Q9NPX7; Q9UFV6

Genbank Protein ID

AK075023; AK290815; AK293495; AL121772; AL353812; AL121772; AL353812; AL353812; AL121772; AL353812; AL121772; CH471133; BC014049; AL117442

Genbank Nucleotide ID

BAC11357.1; BAF83504.1; BAG56982.1; CAI23474.1; CAI23474.1; CAI23475.1; CAI23475.1; CAI13762.1; CAI13762.1; CAI13763.1; CAI13763.1; EAX10089.1; AAH14049.1; CAB55927.1

Protein Name

Monoacylglycerol lipase ABHD12

Protein Synonyms/Alias

2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 12

Gene Name

ABHD12

Gene Synonyms/Alias

C20orf22

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
358	ARSFRDFKVQFVPFH	ubiquitination	[1]

Reference

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]

Functional Description

Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity).

Sequence Annotation

ACT_SITE 246 246 Charge relay system (By similarity).
ACT_SITE 333 333 Charge relay system (By similarity).
ACT_SITE 372 372 Charge relay system (By similarity).

Keyword

Alternative splicing; Cataract; Complete proteome; Deafness; Glycoprotein; Hydrolase; Membrane; Neuropathy; Polymorphism; Reference proteome; Retinitis pigmentosa; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

398 AA

Protein Sequence

MRKRTEPVAL EHERCAAAGS SSSGSAAAAL DADCRLKQNL RLTGPAAAEP RCAADAGMKR 60
ALGRRKGVWL RLRKILFCVL GLYIAIPFLI KLCPGIQAKL IFLNFVRVPY FIDLKKPQDQ 120
GLNHTCNYYL QPEEDVTIGV WHTVPAVWWK NAQGKDQMWY EDALASSHPI ILYLHGNAGT 180
RGGDHRVELY KVLSSLGYHV VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKARSGDNPV 240
YIWGHSLGTG VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF 300
FLDPITSSGI KFANDENVKH ISCPLLILHA EDDPVVPFQL GRKLYSIAAP ARSFRDFKVQ 360
FVPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPEHQH 398

Gene Ontology

GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0047372; F:acylglycerol lipase activity; IEA:EC.

Interpro

IPR026605; ABHD12.

Pfam

SMART

PROSITE

PRINTS