Tag | Content |
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CPLM ID | CPLM-014870 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Quinone oxidoreductase |
Protein Synonyms/Alias | NADPH:quinone reductase; Zeta-crystallin |
Gene Name | Cryz |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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6 | **MATGQKLMRAIRV | acetylation | [1] | 23 | FGGPEVLKLQSDVVV | acetylation | [1] | 88 | GDGVSAFKKGDRVFC | acetylation | [1] | 175 | IARAHGLKVLGTAGS | acetylation | [1] | 186 | TAGSEEGKKLVLQNG | acetylation | [1] | 187 | AGSEEGKKLVLQNGA | acetylation | [1] | 201 | AHEVFNHKEANYIDK | acetylation | [1] | 208 | KEANYIDKIKTSAGD | acetylation | [1] | 210 | ANYIDKIKTSAGDKG | acetylation | [1] | 216 | IKTSAGDKGVDVIIE | acetylation | [1] | 228 | IIEMLANKNLSNDLK | acetylation | [1] | 235 | KNLSNDLKLLSCGGR | acetylation | [1] | 296 | GIEKGWVKPVIGSEY | acetylation | [1] | 307 | GSEYPLEKAAQAHED | acetylation | [1] | 321 | DIIHSSGKMGKMILL | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity). |
Sequence Annotation | NP_BIND 158 161 NADP (By similarity). NP_BIND 246 249 NADP (By similarity). NP_BIND 269 271 NADP (By similarity). BINDING 53 53 NADP (By similarity). BINDING 181 181 NADP; via amide nitrogen (By similarity). BINDING 200 200 NADP (By similarity). BINDING 229 229 NADP (By similarity). MOD_RES 23 23 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Reference proteome; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 329 AA |
Protein Sequence | MATGQKLMRA IRVFEFGGPE VLKLQSDVVV PAPQSHQVLI KVHACGVNPV ETYIRSGTYS 60 RKPALPYTPG SDVAGIIESV GDGVSAFKKG DRVFCFSTVS GGYAEFALSA DNTTYPLPET 120 LDFRQGAALG IPYFTACRAL FHSARARAGE SVLVHGASGG VGLATCQIAR AHGLKVLGTA 180 GSEEGKKLVL QNGAHEVFNH KEANYIDKIK TSAGDKGVDV IIEMLANKNL SNDLKLLSCG 240 GRVIVVGCRG SIEINPRDTM AKETSIIGVS LFSSTKEEFQ QFAGILQAGI EKGWVKPVIG 300 SEYPLEKAAQ AHEDIIHSSG KMGKMILLL 329 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |