CPLM-024045

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-024045

UniProt Accession

CMTA1_HUMAN; Q9Y6Y1; A7MBM4; G3V3Z7; Q5VUE1; Q6V701; Q8WYI3; Q96S92

Genbank Protein ID

AB020640; AY037153; AL590128; AL359881; AL365194; AL596210; Z97635; Z98052; Z98884; AL359881; AL365194; AL590128; AL596210; Z97635; Z98884; Z98052; AL596210; AL359881; AL365194; AL590128; Z97635; Z98052; Z98884; Z97635; Z98884; Z98052; AL596210; AL590128; AL365194; AL359881; Z98884; Z98052; Z97635; AL359881; AL365194; AL596210; AL590128; Z98052; Z98884; Z97635; AL359881; AL596210; AL590128; AL365194; AL365194; AL359881; AL590128; AL596210; Z97635; Z98052; Z98884; CH471130; BC116457; BC151835; CD103791; AF111804; AY349360

Genbank Nucleotide ID

BAA74856.3; AAK67633.1; CAH72347.1; CAH72347.1; CAH72347.1; CAH72347.1; CAH72347.1; CAH72347.1; CAH72347.1; CAH72663.1; CAH72663.1; CAH72663.1; CAH72663.1; CAH72663.1; CAH72663.1; CAH72663.1; CAI17064.1; CAI17064.1; CAI17064.1; CAI17064.1; CAI17064.1; CAI17064.1; CAI17064.1; CAI20961.1; CAI20961.1; CAI20961.1; CAI20961.1; CAI20961.1; CAI20961.1; CAI20961.1; CAI21433.1; CAI21433.1; CAI21433.1; CAI21433.1; CAI21433.1; CAI21433.1; CAI21433.1; CAI21596.1; CAI21596.1; CAI21596.1; CAI21596.1; CAI21596.1; CAI21596.1; CAI21596.1; CAI21790.1; CAI21790.1; CAI21790.1; CAI21790.1; CAI21790.1; CAI21790.1; CAI21790.1; EAW71580.1; AAI16458.1; AAI51836.1; AAL39006.1; AAQ56724.1

Protein Name

Calmodulin-binding transcription activator 1

Protein Synonyms/Alias

Gene Name

CAMTA1

Gene Synonyms/Alias

KIAA0833; MSTP023

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
7	*MWRAEGKWLPKTSR	ubiquitination	[1]
56	VKIFLPKKLLECLPK	ubiquitination	[1, 2]
1247	YPAPKKHKLNPEYFQ	acetylation	[3]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[3] Regulation of cellular metabolism by protein lysine acetylation.
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]

Functional Description

Transcriptional activator. May act as a tumor suppressor.

Sequence Annotation

DOMAIN 873 953 IPT/TIG.
REPEAT 1064 1093 ANK 1.
REPEAT 1109 1129 ANK 2.
REPEAT 1143 1172 ANK 3.
DOMAIN 1547 1576 IQ 1.
DOMAIN 1577 1599 IQ 2.
DOMAIN 1600 1622 IQ 3.
DNA_BIND 63 188 CG-1.
MOTIF 112 119 Nuclear localization signal (Potential).

Keyword

3D-structure; Activator; Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Mental retardation; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1673 AA

Protein Sequence

MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK IFLPKKLLEC 60
LPKCSSLPKE RHRWNTNEEI AAYLITFEKH EEWLTTSPKT RPQNGSMILY NRKKVKYRKD 120
GYCWKKRKDG KTTREDHMKL KVQGVECLYG CYVHSSIIPT FHRRCYWLLQ NPDIVLVHYL 180
NVPAIEDCGK PCGPILCSIN TDKKEWAKWT KEELIGQLKP MFHGIKWTCS NGNSSSGFSV 240
EQLVQQILDS HQTKPQPRTH NCLCTGSLGA GGSVHHKCNS AKHRIISPKV EPRTGGYGSH 300
SEVQHNDVSE GKHEHSHSKG SSREKRNGKV AKPVLLHQSS TEVSSTNQVE VPDTTQSSPV 360
SISSGLNSDP DMVDSPVVTG VSGMAVASVM GSLSQSATVF MSEVTNEAVY TMSPTAGPNH 420
HLLSPDASQG LVLAVSSDGH KFAFPTTGSS ESLSMLPTNV SEELVLSTTL DGGRKIPETT 480
MNFDPDCFLN NPKQGQTYGG GGLKAEMVSS NIRHSPPGER SFSFTTVLTK EIKTEDTSFE 540
QQMAKEAYSS SAAAVAASSL TLTAGSSLLP SGGGLSPSTT LEQMDFSAID SNKDYTSSFS 600
QTGHSPHIHQ TPSPSFFLQD ASKPLPVEQN THSSLSDSGG TFVMPTVKTE ASSQTSSCSG 660
HVETRIESTS SLHLMQFQAN FQAMTAEGEV TMETSQAAEG SEVLLKSGEL QACSSEHYLQ 720
PETNGVIRSA GGVPILPGNV VQGLYPVAQP SLGNASNMEL SLDHFDISFS NQFSDLINDF 780
ISVEGGSSTI YGHQLVSGDS TALSQSEDGA RAPFTQAEMC LPCCSPQQGS LQLSSSEGGA 840
STMAYMHVAE VVSAASAQGT LGMLQQSGRV FMVTDYSPEW SYPEGGVKVL ITGPWQEASN 900
NYSCLFDQIS VPASLIQPGV LRCYCPAHDT GLVTLQVAFN NQIISNSVVF EYKARALPTL 960
PSSQHDWLSL DDNQFRMSIL ERLEQMERRM AEMTGSQQHK QASGGGSSGG GSGSGNGGSQ 1020
AQCASGTGAL GSCFESRVVV VCEKMMSRAC WAKSKHLIHS KTFRGMTLLH LAAAQGYATL 1080
IQTLIKWRTK HADSIDLELE VDPLNVDHFS CTPLMWACAL GHLEAAVVLY KWDRRAISIP 1140
DSLGRLPLGI ARSRGHVKLA ECLEHLQRDE QAQLGQNPRI HCPASEEPST ESWMAQWHSE 1200
AISSPEIPKG VTVIASTNPE LRRPRSEPSN YYSSESHKDY PAPKKHKLNP EYFQTRQEKL 1260
LPTALSLEEP NIRKQSPSSK QSVPETLSPS EGVRDFSREL SPPTPETAAF QASGSQPVGK 1320
WNSKDLYIGV STVQVTGNPK GTSVGKEAAP SQVRPREPMS VLMMANREVV NTELGSYRDS 1380
AENEECGQPM DDIQVNMMTL AEHIIEATPD RIKQENFVPM ESSGLERTDP ATISSTMSWL 1440
ASYLADADCL PSAAQIRSAY NEPLTPSSNT SLSPVGSPVS EIAFEKPNLP SAADWSEFLS 1500
ASTSEKVENE FAQLTLSDHE QRELYEAARL VQTAFRKYKG RPLREQQEVA AAVIQRCYRK 1560
YKQYALYKKM TQAAILIQSK FRSYYEQKKF QQSRRAAVLI QKYYRSYKKC GKRRQARRTA 1620
VIVQQKLRSS LLTKKQDQAA RKIMRFLRRC RHSPLVDHRL YKRSERIEKG QGT 1673

Gene Ontology

GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005634; C:nucleus; IDA:HPA.
GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.

Interpro

IPR002110; Ankyrin_rpt.
IPR020683; Ankyrin_rpt-contain_dom.
IPR005559; CG-1_dom.
IPR013783; Ig-like_fold.
IPR014756; Ig_E-set.
IPR002909; IPT_TIG_rcpt.
IPR000048; IQ_motif_EF-hand-BS.
IPR027417; P-loop_NTPase.

Pfam

PF03859; CG-1
PF00612; IQ
PF01833; TIG

SMART

SM00248; ANK
SM01076; CG-1
SM00015; IQ

PROSITE

PS50297; ANK_REP_REGION
PS50088; ANK_REPEAT
PS51437; CG_1
PS50096; IQ

PRINTS