CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039821
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase ULK1 
Protein Synonyms/Alias
  
Gene Name
 ULK1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
57GIIHRDLKPQNILLSubiquitination[1]
79NPNSIRVKIADFGFAubiquitination[1]
154RLFYEKNKTLVPTIPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 184 AA 
Protein Sequence
MANSVYLVME YCNGGDLADY LHAMRTLSED TIRLFLQQIA GAMRLLHSKG IIHRDLKPQN 60
ILLSNPAGRR ANPNSIRVKI ADFGFARYLQ SNMMAATLCG SPMYMAPEVI MSQHYDGKAD 120
LWSIGTIVYQ CLTGKAPFQA SSPQDLRLFY EKNKTLVPTI PRETSAPLRQ LLLALLQRNH 180
KDRM 184 
Gene Ontology
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0034045; C:pre-autophagosomal structure membrane; IEA:Compara.
 GO:0070969; C:ULK1-ATG13-FIP200 complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:Compara.
 GO:0000045; P:autophagic vacuole assembly; IEA:Compara.
 GO:0048675; P:axon extension; IEA:Compara.
 GO:0021707; P:cerebellar granule cell differentiation; IEA:Compara.
 GO:0048671; P:negative regulation of collateral sprouting; IEA:Compara.
 GO:0031102; P:neuron projection regeneration; IEA:Compara.
 GO:0010508; P:positive regulation of autophagy; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0021933; P:radial glia guided migration of cerebellar granule cell; IEA:Compara.
 GO:0007265; P:Ras protein signal transduction; IEA:Compara.
 GO:0031623; P:receptor internalization; IEA:Compara.
 GO:0051386; P:regulation of neurotrophin TRK receptor signaling pathway; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS