| Tag | Content |
|---|
| CPLM ID | CPLM-024136 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RasGAP-activating-like protein 1 |
Protein Synonyms/Alias | |
Gene Name | Rasal1 |
Gene Synonyms/Alias | Rasal |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 348 | RSNSLASKSMEQFMK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probable inhibitory regulator of the Ras-cyclic AMP pathway. |
Sequence Annotation | DOMAIN 1 88 C2 1.
DOMAIN 135 216 C2 2.
DOMAIN 300 510 Ras-GAP.
DOMAIN 565 672 PH.
ZN_FING 674 710 Btk-type. |
Keyword | Complete proteome; GTPase activation; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 799 AA |
Protein Sequence | MAKSGSLSIR VVEGRALPAK DVSGSSDPYC LVKVDDQVVA RTATIWRSLS PFWGEEYTVH 60
LPLDFHHLAF YVLDEDTVGH DDIIGKISLS KEAITADPRG IDSWINLSRV DPDAEVQGEV 120
CLDVKLLEDA RGRCLRCHVR QARDLAPRDI SGTSDPFARV FWGNHSLETS TIKKTRFPHW 180
DEVLELREAP GTTSPLRVEL WDWDMVGKND FLGMVEFTPQ TLQQKPPNGW FRLLPFPRAE 240
DSGGSLGALR LKVRLTEDRV LPSQYYQPLM ELLLESVQGP AEEDTTSPLA LLEELASGDC 300
RQDLATKLVK LFLGRGLAGP FLDYLTRREV ARTNDPNTLF RSNSLASKSM EQFMKLVGMR 360
YLHEVLRPVI SRVFEEKKYM ELDPCKMDLN RSRRISFKGT PTEEQVRETS LGLLTGYLGS 420
VVDAIVSSTG RCPLALRLAF KQLQRCVEKR FSGIEHQDVK YLAISGFLFL RFFAPAILTP 480
KLFDLRDQHA DPQTSRSLLL LAKAVQSIGN LGQQLGQGKE QWLAPLHPFL LQSISRVRDF 540
LDQLVDVDED EEAGGPACAL VQPSTIVREG FLLKRKEEPG GLATRFAFKK RYFRLSGRDL 600
SYSKTPEWQV HTSIPLSCIR AVEHVDEGAF QLPHVMQVVT QDGAGTSHTT YLQCKNVNDL 660
NQWLSALRKA SAPNPGKLVA CHPGAFRSGR WTCCLQAERS AAGCSRTHSA ITLGDWSDPL 720
DPDAEAQAVY RQLLLGRDQL RLKLLEDSSL DTEVDPGRDS SATDGPCAEV LAQQRAATTH 780
LLQVLEDLEQ AHEEFQKRG 799 |
Gene Ontology | GO:0005737; C:cytoplasm; IBA:RefGenome. GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |