CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005778
UniProt Accession
Genbank Protein ID
 M58526; AL034369; AL031622; AL035425; AL035425; AL031622; AL034369; AL031622; AL034369; AL035425; AL136364; CH471120; M90464; U04520; U04470; U04471; U04472; U04473; U04474; U04476; U04477; U04478; U04479; U04480; U04483; U04485; U04486; U04487; U04488; U04489; U04490; U04491; U04492; U04493; U04494; U04495; U04496; U04497; U04498; U04499; U04500; U04501; U04502; U04503; U04504; U04505; U04506; U04507; U04508; U04509; U04510; U04511; U04512; U04514; U04515; U04516; U04517; U04518; U04519; U04520; U04470; U04471; U04472; U04473; U04474; U04476; U04477; U04478; U04479; U04480; U04483; U04485; U04486; U04487; U04488; U04489; U04490; U04491; U04492; U04493; U04494; U04495; U04496; U04497; U04498; U04499; U04500; U04501; U04502; U04503; U04504; U04505; U04506; U04507; U04508; U04509; U04510; AF199451; AF199452; U04511; U04512; U04514; U04515; U04516; U04517; U04518; U04519; M63473; M63455; M63456; M63457; M63458; M63459; M63460; M63461; M63462; M63463; M63464; M63465; M63466; M63467; M63468; M63470; M63471; M63472; M31115; Z37153; S69168; S59334; S75903 
Genbank Nucleotide ID
 AAA99480.1; CAA22267.2; CAA22267.2; CAA22267.2; CAB90289.2; CAB90289.2; CAB90289.2; CAI43038.1; CAI43038.1; CAI43038.1; EAX02683.1; AAA52046.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAC27816.1; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAF66217.2; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA51558.1; AAA52045.1; CAA85512.1; AAC60612.1; AAD13909.1; AAB33374.1 
Protein Name
 Collagen alpha-5(IV) chain 
Protein Synonyms/Alias
  
Gene Name
 COL4A5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1496LLYVQGNKRAHGQDLglycation[1]
Reference
 [1] Glucose autoxidation induces functional damage to proteins via modification of critical arginine residues.
 Chetyrkin S, Mathis M, Pedchenko V, Sanchez OA, McDonald WH, Hachey DL, Madu H, Stec D, Hudson B, Voziyan P.
 Biochemistry. 2011 Jul 12;50(27):6102-12. [PMID: 21661747] 
Functional Description
 Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. 
Sequence Annotation
 DOMAIN 1461 1685 Collagen IV NC1.
 REGION 27 41 Nonhelical region (NC2).
 REGION 42 1456 Triple-helical region.
 CARBOHYD 125 125 N-linked (GlcNAc...) (Potential).
 DISULFID 451 451 Interchain (Potential).
 DISULFID 481 481 Interchain (Potential).
 DISULFID 484 484 Interchain (Potential).
 DISULFID 1476 1567 Or C-1476 with C-1564 (By similarity).
 DISULFID 1509 1564 Or C-1509 with C-1567 (By similarity).
 DISULFID 1521 1527 By similarity.
 DISULFID 1586 1681 Or C-1586 with C-1678 (By similarity).
 DISULFID 1620 1678 Or C-1620 with C-1681 (By similarity).
 DISULFID 1632 1638 By similarity.
 CROSSLNK 1549 1549 S-Lysyl-methionine sulfilimine (Met-Lys)
 CROSSLNK 1667 1667 S-Lysyl-methionine sulfilimine (Lys-Met)  
Keyword
 Alport syndrome; Alternative splicing; Basement membrane; Chromosomal rearrangement; Collagen; Complete proteome; Deafness; Disease mutation; Disulfide bond; Extracellular matrix; Glycoprotein; Hydroxylation; Polymorphism; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1685 AA 
Protein Sequence
MKLRGVSLAA GLFLLALSLW GQPAEAAACY GCSPGSKCDC SGIKGEKGER GFPGLEGHPG 60
LPGFPGPEGP PGPRGQKGDD GIPGPPGPKG IRGPPGLPGF PGTPGLPGMP GHDGAPGPQG 120
IPGCNGTKGE RGFPGSPGFP GLQGPPGPPG IPGMKGEPGS IIMSSLPGPK GNPGYPGPPG 180
IQGLPGPTGI PGPIGPPGPP GLMGPPGPPG LPGPKGNMGL NFQGPKGEKG EQGLQGPPGP 240
PGQISEQKRP IDVEFQKGDQ GLPGDRGPPG PPGIRGPPGP PGGEKGEKGE QGEPGKRGKP 300
GKDGENGQPG IPGLPGDPGY PGEPGRDGEK GQKGDTGPPG PPGLVIPRPG TGITIGEKGN 360
IGLPGLPGEK GERGFPGIQG PPGLPGPPGA AVMGPPGPPG FPGERGQKGD EGPPGISIPG 420
PPGLDGQPGA PGLPGPPGPA GPHIPPSDEI CEPGPPGPPG SPGDKGLQGE QGVKGDKGDT 480
CFNCIGTGIS GPPGQPGLPG LPGPPGSLGF PGQKGEKGQA GATGPKGLPG IPGAPGAPGF 540
PGSKGEPGDI LTFPGMKGDK GELGSPGAPG LPGLPGTPGQ DGLPGLPGPK GEPGGITFKG 600
ERGPPGNPGL PGLPGNIGPM GPPGFGPPGP VGEKGIQGVA GNPGQPGIPG PKGDPGQTIT 660
QPGKPGLPGN PGRDGDVGLP GDPGLPGQPG LPGIPGSKGE PGIPGIGLPG PPGPKGFPGI 720
PGPPGAPGTP GRIGLEGPPG PPGFPGPKGE PGFALPGPPG PPGLPGFKGA LGPKGDRGFP 780
GPPGPPGRTG LDGLPGPKGD VGPNGQPGPM GPPGLPGIGV QGPPGPPGIP GPIGQPGLHG 840
IPGEKGDPGP PGLDVPGPPG ERGSPGIPGA PGPIGPPGSP GLPGKAGASG FPGTKGEMGM 900
MGPPGPPGPL GIPGRSGVPG LKGDDGLQGQ PGLPGPTGEK GSKGEPGLPG PPGPMDPNLL 960
GSKGEKGEPG LPGIPGVSGP KGYQGLPGDP GQPGLSGQPG LPGPPGPKGN PGLPGQPGLI 1020
GPPGLKGTIG DMGFPGPQGV EGPPGPSGVP GQPGSPGLPG QKGDKGDPGI SSIGLPGLPG 1080
PKGEPGLPGY PGNPGIKGSV GDPGLPGLPG TPGAKGQPGL PGFPGTPGPP GPKGISGPPG 1140
NPGLPGEPGP VGGGGHPGQP GPPGEKGKPG QDGIPGPAGQ KGEPGQPGFG NPGPPGLPGL 1200
SGQKGDGGLP GIPGNPGLPG PKGEPGFHGF PGVQGPPGPP GSPGPALEGP KGNPGPQGPP 1260
GRPGLPGPEG PPGLPGNGGI KGEKGNPGQP GLPGLPGLKG DQGPPGLQGN PGRPGLNGMK 1320
GDPGLPGVPG FPGMKGPSGV PGSAGPEGEP GLIGPPGPPG LPGPSGQSII IKGDAGPPGI 1380
PGQPGLKGLP GPQGPQGLPG PTGPPGDPGR NGLPGFDGAG GRKGDPGLPG QPGTRGLDGP 1440
PGPDGLQGPP GPPGTSSVAH GFLITRHSQT TDAPQCPQGT LQVYEGFSLL YVQGNKRAHG 1500
QDLGTAGSCL RRFSTMPFMF CNINNVCNFA SRNDYSYWLS TPEPMPMSMQ PLKGQSIQPF 1560
ISRCAVCEAP AVVIAVHSQT IQIPHCPQGW DSLWIGYSFM MHTSAGAEGS GQALASPGSC 1620
LEEFRSAPFI ECHGRGTCNY YANSYSFWLA TVDVSDMFSK PQSETLKAGD LRTRISRCQV 1680
CMKRT 1685 
Gene Ontology
 GO:0005605; C:basal lamina; IEA:Compara.
 GO:0005587; C:collagen type IV; TAS:ProtInc.
 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0030574; P:collagen catabolic process; TAS:Reactome.
 GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
 GO:0007528; P:neuromuscular junction development; IEA:Compara. 
Interpro
 IPR016187; C-type_lectin_fold.
 IPR008160; Collagen.
 IPR001442; Collagen_VI_NC. 
Pfam
 PF01413; C4
 PF01391; Collagen 
SMART
 SM00111; C4 
PROSITE
 PS51403; NC1_IV 
PRINTS