CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017308
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uncharacterized protein C8orf59 
Protein Synonyms/Alias
  
Gene Name
 C8orf59 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21VFHIASQKNFKAKNKacetylation[1]
21VFHIASQKNFKAKNKubiquitination[2, 3, 4, 5]
59KAFVNVQKELAHFAKubiquitination[3]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 MOD_RES 21 21 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 98 AA 
Protein Sequence
MAKNKLRGPK SRNVFHIASQ KNFKAKNKAK PVTTNLKKIN IMNEEKVNRV NKAFVNVQKE 60
LAHFAKSISL EPLQKELIPQ QRHESKPVDE ATRLMALL 98 
Gene Ontology
  
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS