CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018907
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 V-type proton ATPase 116 kDa subunit a isoform 1 
Protein Synonyms/Alias
 V-ATPase 116 kDa isoform a1; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 
Gene Name
 ATP6V0A1 
Gene Synonyms/Alias
 ATP6N1; ATP6N1A; VPP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
70RKLRFVEKEIRKANIubiquitination[1]
74FVEKEIRKANIPIMDubiquitination[1]
242QLKNRVKKICEGFRAubiquitination[1]
373QTPPTYNKTNKFTYGubiquitination[1]
673RRQYLRRKHLGTLNFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). 
Sequence Annotation
 MOD_RES 250 250 Phosphothreonine (By similarity).
 MOD_RES 364 364 Phosphotyrosine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasmic vesicle; Hydrogen ion transport; Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 837 AA 
Protein Sequence
MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE 60
MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAN FEKIENELKE INTNQEALKR 120
NFLELTELKF ILRKTQQFFD EAELHHQQMA DPDLLEESSS LLEPSEMGRG TPLRLGFVAG 180
VINRERIPTF ERMLWRVCRG NVFLRQAEIE NPLEDPVTGD YVHKSVFIIF FQGDQLKNRV 240
KKICEGFRAS LYPCPETPQE RKEMASGVNT RIDDLQMVLN QTEDHRQRVL QAAAKNIRVW 300
FIKVRKMKAI YHTLNLCNID VTQKCLIAEV WCPVTDLDSI QFALRRGTEH SGSTVPSILN 360
RMQTNQTPPT YNKTNKFTYG FQNIVDAYGI GTYREINPAP YTIITFPFLF AVMFGDFGHG 420
ILMTLFAVWM VLRESRILSQ KNENEMFSTV FSGRYIILLM GVFSMYTGLI YNDCFSKSLN 480
IFGSSWSVRP MFTYNWTEET LRGNPVLQLN PALPGVFGGP YPFGIDPIWN IATNKLTFLN 540
SFKMKMSVIL GIIHMLFGVS LSLFNHIYFK KPLNIYFGFI PEIIFMTSLF GYLVILIFYK 600
WTAYDAHTSE NAPSLLIHFI NMFLFSYPES GYSMLYSGQK GIQCFLVVVA LLCVPWMLLF 660
KPLVLRRQYL RRKHLGTLNF GGIRVGNGPT EEDAEIIQHD QLSTHSEDAD EFDFGDTMVH 720
QAIHTIEYCL GCISNTASYL RLWALSLAHA QLSEVLWTMV IHIGLSVKSL AGGLVLFFFF 780
TAFATLTVAI LLIMEGLSAF LHALRLHWVE FQNKFYSGTG FKFLPFSFEH IREGKFEE 838 
Gene Ontology
 GO:0010008; C:endosome membrane; TAS:Reactome.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
 GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
 GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
 GO:0051701; P:interaction with host; TAS:Reactome.
 GO:0090382; P:phagosome maturation; TAS:Reactome.
 GO:0033572; P:transferrin transport; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 
Interpro
 IPR002490; V-ATPase_116kDa_su.
 IPR026028; V-type_ATPase_116kDa_su_euka. 
Pfam
 PF01496; V_ATPase_I 
SMART
  
PROSITE
  
PRINTS