CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040021
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Voltage-dependent anion-selective channel protein 3 
Protein Synonyms/Alias
  
Gene Name
 VDAC3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12PTYCDLGKAAKDVFNubiquitination[1]
15CDLGKAAKDVFNKGYubiquitination[1, 2]
20AAKDVFNKGYGFGMVubiquitination[1, 2]
111FVPNTGKKSGKLKASubiquitination[1]
164SFDTAKSKLSQNNFAacetylation[3]
164SFDTAKSKLSQNNFAubiquitination[1, 4, 5, 6]
267LSALIDGKNFSAGGHubiquitination[4, 6]
275NFSAGGHKVGLGFELubiquitination[4, 5, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 284 AA 
Protein Sequence
MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVV EFSTSGHAYT DTGKASGNLE 60
TKYKVCNYGL TFTQKWNTDN TLGTEISWEN KLAEGLKLTL DTIFVPNTGK KSGKLKASYK 120
RDCFSVGSNV DIDFSGPTIY GWAVLAFEGW LAGYQMSFDT AKSKLSQNNF ALGYKAADFQ 180
LHTHVNDGTE FGGSIYQKVN EKIETSINLA WTAGSNNTRF GIAAKYMLDC RTSLSAKVNN 240
ASLIGLGYTQ TLRPGVKLTL SALIDGKNFS AGGHKVGLGF ELEA 284 
Gene Ontology
 GO:0005741; C:mitochondrial outer membrane; IEA:InterPro.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0008308; F:voltage-gated anion channel activity; IEA:InterPro. 
Interpro
 IPR023614; Porin_dom.
 IPR001925; Porin_Euk.
 IPR027246; Porin_Euk/Tom40. 
Pfam
 PF01459; Porin_3 
SMART
  
PROSITE
 PS00558; EUKARYOTIC_PORIN 
PRINTS
 PR00185; EUKARYTPORIN.