CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041799
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MCG123888 
Protein Synonyms/Alias
 MKL/myocardin-like protein 2 
Gene Name
 Mkl2 
Gene Synonyms/Alias
 mCG_123888 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
794GQPQPVRKVFTNSAPubiquitination[1]
822NQQPFVSKTSNPALQacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1091 AA 
Protein Sequence
MDHTGAIDTE EELGPLAHLA PSPQSESVAH EFQELSLQSS QHLPTLNERK NVLQLRLQQR 60
RTREQLVDQG IMPPLKSPAA FHEQIKSLER ARTENFLKHK IRSRPDRSEL VRMHILEETF 120
AEPSLQATQM KLKRARLADD LNEKIAQRPG PMELVEKNIL PVDSSVKEAI IGVVKEDYPH 180
THGEFSFDED SSDALSPDQP ASQESQGSAA SPSEPKVSAS PPPVTASTPA QFTSVSPAVP 240
EFLKTPLTAD QPPTRSTAPV LPTNTVSSAK SGPMLVKQSH PKNPNDKHRS KKCKDPKPRV 300
KKLKYHQYIP PNQKGEKSEP QMDSNYARLL QQQQLFLQLQ ILSQQQQQQQ QQHYNYQTIL 360
PAPIKTDKNS SSGSNSGSSS SMPARRPGPL PSSLDDLKVS ELKTELKLRG LPVSGTKPDL 420
IERLKPYQEV TSSNLATGSI VAVSSATIVT SNPEVTVALP VTTLHNAVTS SVSTFKADLA 480
LPATSSVPHV ENAHSPLPIS PSPSEQSSLS TDDTNMTDTF TEIMTMMSPS QLLCSSPLRV 540
VSHDDSLSPS SSTLSTLELD AAEKDRKLQE KEKQIEELKR KLEQEQKLVE VLKMQLEVEK 600
RGQQRPPDPQ PSDPPHPFNT SDPKHGSVGS SIKDEASLPD CSSPQQPITV PGHSVGQPIS 660
TGSQTLVAKK TVVVKQEVPM AQAEQQNVVS QFYLSSQGQP PALVAQPQAL LTTQTTQLLL 720
PVSIQGSNVT SVQLPVGSLQ LQTPAQGRVQ AQPHVAAATQ VPAAALPSAL TSALPQKQEA 780
FPQHVLGQPQ PVRKVFTNSA PNTVLQYQRQ PGPTNQQPFV SKTSNPALQS RTAPLAPLQN 840
GPSLASKPSS PPPPQQFVVQ HSLFATPITK TKDPPRYEEA IKQARSTQPA LPEVSSVHSQ 900
QMDDLFDILI KSGEISFPIK EEPSPISKMK PVTASITTMP VNTVVSRPPP QVQIAPPVSL 960
EPVNSLSASL ENQLEAFLDG TLPSATDTGP LQNSSEDRES FSLIEDLQND LLSHSSMLYQ 1020
SHSPMETSEA QLVSGTPCLS LDLSDSNLDN MEWLDITMPT TSSGLTPLST TAPSMFSADF 1080
LDPQDLPLPW D 1091 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0048514; P:blood vessel morphogenesis; IMP:MGI.
 GO:0048738; P:cardiac muscle tissue development; IMP:MGI.
 GO:0048568; P:embryonic organ development; IMP:MGI.
 GO:0010467; P:gene expression; IMP:MGI.
 GO:0003007; P:heart morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0001889; P:liver development; IMP:MGI.
 GO:0045844; P:positive regulation of striated muscle tissue development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0051145; P:smooth muscle cell differentiation; IMP:MGI. 
Interpro
 IPR004018; RPEL_repeat.
 IPR003034; SAP_dom. 
Pfam
 PF02755; RPEL
 PF02037; SAP 
SMART
 SM00707; RPEL
 SM00513; SAP 
PROSITE
 PS51073; RPEL
 PS50800; SAP 
PRINTS