| Tag | Content |
|---|
| CPLM ID | CPLM-010437 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Death domain-containing protein CRADD |
Protein Synonyms/Alias | Caspase and RIP adapter with death domain; RIP-associated protein with a death domain |
Gene Name | CRADD |
Gene Synonyms/Alias | RAIDD |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 53 | AQTTGLRKTMLLLDI | ubiquitination | [1] | | 173 | RWRQRFGKQATFQSL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. |
Sequence Annotation | DOMAIN 1 91 CARD.
DOMAIN 116 188 Death. |
Keyword | 3D-structure; Apoptosis; Complete proteome; Cytoplasm; Disease mutation; Mental retardation; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 199 AA |
Protein Sequence | MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEINAQTTG LRKTMLLLDI 60
LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG DRLTGIPSHI LNSSPSDRQI 120
NQLAQRLGPE WEPMVLSLGL SQTDIYRCKA NHPHNVQSQV VEAFIRWRQR FGKQATFQSL 180
HNGLRAVEVD PSLLLHMLE 199 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB. GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IMP:UniProtKB. GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IC:BHF-UCL. GO:0042981; P:regulation of apoptotic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |