| Tag | Content |
|---|
| CPLM ID | CPLM-016011 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein LAP2 |
Protein Synonyms/Alias | Densin-180-like protein; Erbb2-interacting protein; Erbin |
Gene Name | Erbb2ip |
Gene Synonyms/Alias | Erbin; Kiaa1225; Lap2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 162 | ANFGRLTKLQILELR | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state (By similarity). |
Sequence Annotation | REPEAT 23 44 LRR 1.
REPEAT 47 68 LRR 2.
REPEAT 70 91 LRR 3.
REPEAT 93 114 LRR 4.
REPEAT 116 137 LRR 5.
REPEAT 139 161 LRR 6.
REPEAT 162 183 LRR 7.
REPEAT 185 206 LRR 8.
REPEAT 208 229 LRR 9.
REPEAT 231 252 LRR 10.
REPEAT 254 275 LRR 11.
REPEAT 277 298 LRR 12.
REPEAT 300 321 LRR 13.
REPEAT 323 344 LRR 14.
REPEAT 346 367 LRR 15.
REPEAT 369 391 LRR 16.
REPEAT 392 413 LRR 17.
DOMAIN 1311 1400 PDZ.
MOD_RES 440 440 Phosphoserine (By similarity).
MOD_RES 595 595 Phosphoserine.
MOD_RES 599 599 Phosphoserine.
MOD_RES 600 600 Phosphoserine.
MOD_RES 712 712 Phosphoserine.
MOD_RES 850 850 Phosphothreonine.
MOD_RES 854 854 Phosphoserine.
MOD_RES 869 869 Phosphoserine.
MOD_RES 914 914 Phosphothreonine (By similarity).
MOD_RES 917 917 Phosphotyrosine (By similarity).
MOD_RES 928 928 Phosphoserine (By similarity).
MOD_RES 970 970 Phosphotyrosine (By similarity).
MOD_RES 1097 1097 Phosphotyrosine.
MOD_RES 1150 1150 Phosphoserine (By similarity).
MOD_RES 1171 1171 Phosphoserine.
MOD_RES 1276 1276 Phosphoserine. |
Keyword | Alternative splicing; Cell junction; Complete proteome; Leucine-rich repeat; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1402 AA |
Protein Sequence | MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE 60
LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV 120
EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM 180
NRLTQLERLD LGSNEFTEVP EVLEQLSGLR EFWMDGNRLT FIPGFIGSLR QLTYLDVSKN 240
NIEMVEEGIS TCENLQDFLL SSNSLQQLPE TIGSLKNVTT LKIDENQLMY LPDSIGGLRS 300
IEELDCSFNE IEALPSSIGQ LTNMRTFAAD HNYLQQLPPE IGNWKNITVL FLHCNKLETL 360
PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDTETQKM 420
VLTNYMFPQQ PRTEDVMFIS DNESFNPALW EEQRKQRAQV AFECDEDKDE REAPPREGNL 480
KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEESGRDLKQ HEDQQVVNKD KCVKTSESTT 540
TKSKLDEREK YMNSVQKMSE PEAETNGGNL PVTASMKLSG NLKHIVNHDD VFEESEELSS 600
DEEMKMAEMR PPLIESSINQ PKVVALSNNK KDDAKDADSL SDEVTHNSNQ NNSNCSSPSR 660
MSDSVSLNTD SSQDTSLCSP VKQTPVDSNS KVRQEDENFN SLLQNGVNLN NSPEEKFKIN 720
DKKDFKLPEY DLNIEEQLVL IEKDIDSKAT SDDSRQLDHI NMNINKLVTN NIFQPEVMER 780
SKMQDIVLGT GFLSIHPKNE AEHIENGAKF PNLESINKVN GLCEDTAPSP GRVEPQKASS 840
SADVGISKST EDLSPQRSGP TGAVVKSHSI TNMETGGLKI YDILGDDGPQ PPSAAVKIAS 900
AVDGKNIVRS KSATLLYDQP LQVFTAASSS SELLSGTKAV FKFDSNHNPE EPDIIRAATV 960
SGPQSTPHLY GPPQYNVQYS GSATVKDTLW HPKQNPQIDP VSFPPQRLPR SESAENHSYA 1020
KHSANMNFSN HNNVRANTGY HLQQRLAPAR HGEMWAISPN DRLVPAVTRT TIQRQSSVSS 1080
TASVNLGDPT RRTEGDYLSY RELHSMGRTP VMSGSQRPLS ARAYSIDGPN TSRPQSARPS 1140
INEIPERTMS VSDFNYSRTS PSKRPNTRVG SEHSLLDPPG KSKVPHDWRE QVLRHIEAKK 1200
LEKHPQTSSP GECCQDDRFM SEEQNHPSGA LSHRGLPDSL MKMPLSNGQM GQPLRPQAHY 1260
SQTHHPPQAS VARHPSREQL IDYLMLKVAH QPPYTHPHCS PRQGHELAKQ EIRVRVEKDP 1320
ELGFSISGGV GGRGNPFRPD DDGIFVTRVQ PEGPASKLLQ PGDKIIQANG YSFINIEHGQ 1380
AVSLLKTFHN AVDLIIVREV SS 1402 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |