CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006033
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 14-3-3 protein sigma 
Protein Synonyms/Alias
 Epithelial cell marker protein 1; Stratifin 
Gene Name
 SFN 
Gene Synonyms/Alias
 HME1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
49NLLSVAYKNVVGGQRubiquitination[1]
68VLSSIEQKSNEEGSEubiquitination[1]
77NEEGSEEKGPEVREYubiquitination[1]
127QEAMDISKKEMPPTNubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). 
Sequence Annotation
 MOD_RES 5 5 Phosphoserine.
 MOD_RES 64 64 Phosphoserine (By similarity).
 MOD_RES 216 216 Phosphoserine (By similarity).
 MOD_RES 248 248 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Secreted. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 248 AA 
Protein Sequence
MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR 60
VLSSIEQKSN EEGSEEKGPE VREYRVFYLK MKGDYYRYLA EVATGDDKKR IIDSARSAYQ 120
EAMDISKKEM PPTNPIRLGL ALNFSVFHYE IANSPEEAIS LAKTTFDEAM ADLHTLSEDS 180
YKDSTLIMQL LRDNLTLWTA DNAGEEGGEA PQEPQS 216 
Gene Ontology
 GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005615; C:extracellular space; TAS:ProtInc.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008426; F:protein kinase C inhibitor activity; TAS:ProtInc.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IDA:HGNC.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara.
 GO:0043616; P:keratinocyte proliferation; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:HGNC.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0046827; P:positive regulation of protein export from nucleus; IEA:Compara.
 GO:1900740; P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; TAS:Reactome.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:Compara.
 GO:0001836; P:release of cytochrome c from mitochondria; IDA:HGNC.
 GO:0043588; P:skin development; IEA:Compara. 
Interpro
 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 
Pfam
 PF00244; 14-3-3 
SMART
 SM00101; 14_3_3 
PROSITE
 PS00796; 1433_1
 PS00797; 1433_2 
PRINTS
 PR00305; 1433ZETA.