UniProt Accession

 VDAC1_RAT; Q9Z2L0; A1L125; Q3MHT8; Q5M944; Q5M972; Q6IN28; Q6P9W9 

Genbank Protein ID

 AF048828; AB039662; AF268467; BC060558; BC072484; BC087573; BC087657; BC104684; BC127491 

Genbank Nucleotide ID

 AAD02476.1; BAB13473.1; AAF80115.1; AAH60558.1; AAH72484.2; AAH87573.2; AAH87657.2; AAI04685.2; AAI27492.1 

Protein Name

 Voltage-dependent anion-selective channel protein 1 

Protein Synonyms/Alias

 VDAC-1; rVDAC1; Outer mitochondrial membrane protein porin 1 

Gene Name

 Vdac1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
12	PTYADLGKSARDVFT	ubiquitination	[1]
20	SARDVFTKGYGFGLI	ubiquitination	[1]
34	IKLDLKTKSENGLEF	ubiquitination	[1]
53	SANTETTKVNGSLET	acetylation	[2]
61	VNGSLETKYRWTEYG	acetylation	[2]
96	DQLARGLKLTFDSSF	acetylation	[2]
109	SFSPNTGKKNAKIKT	acetylation	[2]
174	SNFAVGYKTDEFQLH	acetylation	[2]
197	FGGSIYQKVNKKLET	acetylation	[2]
274	NVNAGGHKLGLGLEF	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (By similarity). 

Sequence Annotation

 NP_BIND 242 244 NAD (By similarity).
 NP_BIND 260 264 NAD (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 13 13 Phosphoserine.
 MOD_RES 20 20 N6-acetyllysine (By similarity).
 MOD_RES 67 67 Phosphotyrosine (By similarity).
 MOD_RES 137 137 Phosphoserine.
 MOD_RES 266 266 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Apoptosis; Cell membrane; Complete proteome; Direct protein sequencing; Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane; NAD; Nucleotide-binding; Phosphoprotein; Porin; Reference proteome; Transmembrane; Transmembrane beta strand; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 283 AA 

Protein Sequence

Gene Ontology

 GO:0005741; C:mitochondrial outer membrane; IDA:RGD.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0046930; C:pore complex; IEA:UniProtKB-KW.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0015288; F:porin activity; IEA:UniProtKB-KW.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0008308; F:voltage-gated anion channel activity; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006851; P:mitochondrial calcium ion transport; IDA:RGD. 

Interpro

 IPR023614; Porin_dom.
 IPR001925; Porin_Euk.
 IPR027246; Porin_Euk/Tom40. 

Pfam

 PF01459; Porin_3 

SMART

  

PROSITE

 PS00558; EUKARYOTIC_PORIN 

PRINTS

 PR00185; EUKARYTPORIN.